PMID- 24261578
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20211021
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 13
DP  - 2013 Nov 21
TI  - Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review 
      and meta-analysis.
PG  - 183
LID - 10.1186/1471-2377-13-183 [doi]
AB  - BACKGROUND: A wealth of published studies have been published on association 
      between Chlamydia pneumoniae (C.pneumoniae) infection and cerebrovascular (CV) 
      disease, but the results were inconsistent. This meta-analysis provides a 
      systematic review of the available evidence from all serological and pathological 
      studies of CV disease and C.pneumoniae. METHODS: A comprehensive research was 
      conducted of MEDLINE, EMBASE, CNKI, WanFang technological periodical database and 
      reference lists of articles to identify eligible case-control and cohort studies. 
      Odds radio (OR) was calculated for each study outcome. Random effect model was 
      used as pooling method and publication bias was estimated for the results. 
      RESULTS: Fifty-two published studies that met criteria were selected. In case 
      control studies, an association between C.pneumoniae infection and CV disease was 
      revealed by serum specific IgG (OR, 1.61; 95% CI: 1.34 to 1.94), serum IgA (OR, 
      2.33; 95% CI: 1.76 to 3.08) and PCR technique of C.pneumoniae in peripheral blood 
      cells (OR, 1.90; 95% CI: 1.17 to 3.07). No significant association was found in 
      serum anti-C.pneumonae IgM seropositivity or in-situ-detection of C.pneumoniae in 
      arterial biopsies with CV disease. Subgroup analysis by available studies 
      suggested that C.pneumoniae may paly a role in atherosclerotic stroke, but be 
      less significant in stroke of cardioembolism or other etiologies. CONCLUSION: 
      Association between C.pneumoniae infection and CV disease depends on the 
      analytical method adopted, which seems stronger with stroke due to large artery 
      atherosclerosis. Establishing a causal relationship between C.peumoniae infection 
      and CV disease will require more prospective studies with combination of 
      techniques and stratified by etiological subtypes.
FAU - Chen, Juan
AU  - Chen J
AD  - Department of Neurology, Affiliated Qianfoshan Hospital of Shandong University, 
      66 Jingshi Road, Jinan, Shandong province 250014, China. zhumeijia1818@gmail.com.
FAU - Zhu, Meijia
AU  - Zhu M
FAU - Ma, Gaoting
AU  - Ma G
FAU - Zhao, Zhangning
AU  - Zhao Z
FAU - Sun, Zhongwen
AU  - Sun Z
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20131121
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Cerebrovascular Disorders/*etiology/microbiology
MH  - Chlamydophila Infections/*complications
MH  - Chlamydophila pneumoniae/genetics/*pathogenicity
MH  - Databases, Bibliographic/statistics & numerical data
MH  - Humans
PMC - PMC4222774
EDAT- 2013/11/23 06:00
MHDA- 2014/04/05 06:00
PMCR- 2013/11/21
CRDT- 2013/11/23 06:00
PHST- 2013/02/01 00:00 [received]
PHST- 2013/11/12 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PHST- 2013/11/21 00:00 [pmc-release]
AID - 1471-2377-13-183 [pii]
AID - 10.1186/1471-2377-13-183 [doi]
PST - epublish
SO  - BMC Neurol. 2013 Nov 21;13:183. doi: 10.1186/1471-2377-13-183.