PMID- 24262387
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20211021
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 35
IP  - 1
DP  - 2014 Jan
TI  - Tumoricidal activity of human dendritic cells.
PG  - 38-46
LID - S1471-4906(13)00160-9 [pii]
LID - 10.1016/j.it.2013.10.007 [doi]
AB  - Dendritic cells (DCs) are a family of professional antigen-presenting cells 
      (APCs) that are able to initiate innate and adaptive immune responses against 
      pathogens and tumor cells. The DC family is heterogeneous and is classically 
      divided into two main subsets, each with its unique phenotypic and functional 
      characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results 
      have provided intriguing evidence that both DC subsets can also function as 
      direct cytotoxic effector cells; in particular, against cancer cells. In this 
      review, we delve into this understudied function of human DCs and discuss why 
      these so-called killer DCs might become important tools in future cancer 
      immunotherapies.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Tel, Jurjen
AU  - Tel J
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
FAU - Anguille, Sebastien
AU  - Anguille S
AD  - Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute, 
      University of Antwerp, Antwerp, Belgium.
FAU - Waterborg, Claire E J
AU  - Waterborg CE
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
FAU - Smits, Evelien L
AU  - Smits EL
AD  - Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute, 
      University of Antwerp, Antwerp, Belgium; Center for Oncological Research, 
      University of Antwerp, Antwerp, Belgium.
FAU - Figdor, Carl G
AU  - Figdor CG
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
FAU - de Vries, I Jolanda M
AU  - de Vries IJ
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department 
      of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The 
      Netherlands. Electronic address: J.deVries@ncmls.ru.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131118
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Cytokines)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Cytokines/metabolism
MH  - *Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immunotherapy
MH  - Neoplasms/*immunology/metabolism/therapy
MH  - Phenotype
PMC - PMC7106406
OTO - NOTNLM
OT  - TRAIL
OT  - antitumor therapy
OT  - cytotoxicity
OT  - granzyme B
OT  - myeloid dendritic cells
OT  - plasmacytoid dendritic cells
EDAT- 2013/11/23 06:00
MHDA- 2014/07/19 06:00
PMCR- 2013/11/18
CRDT- 2013/11/23 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/10/18 00:00 [revised]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
PHST- 2013/11/18 00:00 [pmc-release]
AID - S1471-4906(13)00160-9 [pii]
AID - 10.1016/j.it.2013.10.007 [doi]
PST - ppublish
SO  - Trends Immunol. 2014 Jan;35(1):38-46. doi: 10.1016/j.it.2013.10.007. Epub 2013 
      Nov 18.