PMID- 24262435 OWN - NLM STAT- MEDLINE DCOM- 20141112 LR - 20200410 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 40 IP - 1 DP - 2014 Feb TI - Persistent organic pollutants and diabetes: a review of the epidemiological evidence. PG - 1-14 LID - S1262-3636(13)00179-1 [pii] LID - 10.1016/j.diabet.2013.09.006 [doi] AB - The prevalence of diabetes and obesity has increased rapidly over the last few decades in both developed and developing countries. While it is intuitively appealing to suggest that lifestyle risk factors such as decreased physical activity and adoption of poor diets can explain much of the increase, the evidence to support this is poor. Given this, there has been an impetus to look more widely than traditional lifestyle and biomedical risk factors, especially those risk factors, which arise from the environment. Since the industrial revolution, there has been an introduction of many chemicals into our environment, which have now become environmental pollutants. There has been growing interest in one key class of environmental pollutants known as persistent organic pollutants (POPs) and their potential role in the development of diabetes. This review will summarise and appraise the current epidemiological evidence relating POPs to diabetes and highlight gaps and flaws in this evidence. CI - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved. FAU - Magliano, D J AU - Magliano DJ AD - Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: dianna.magliano@bakeridi.edu.au. FAU - Loh, V H Y AU - Loh VHY AD - Baker IDI Heart and Diabetes Institute, Melbourne, Australia. FAU - Harding, J L AU - Harding JL AD - Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Botton, J AU - Botton J AD - Inserm, CESP (Centre of Research for Epidemiology and Population Health), U1018, Lifelong Epidemiology of Obesity, Diabetes and Kidney Diseases Team, 94807 Villejuif, France; UMR-S 1018, University Paris-Sud, 94807 Villejuif, France. FAU - Shaw, J E AU - Shaw JE AD - Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20131118 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 RN - 0 (Air Pollutants, Occupational) RN - 0 (Environmental Pollutants) RN - 0 (Glucose Transport Proteins, Facilitative) RN - 0 (Herbicides) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Insulin) RN - 0 (Polychlorinated Dibenzodioxins) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adipose Tissue/*metabolism MH - Air Pollutants, Occupational/*adverse effects MH - Diabetes Mellitus, Type 2/chemically induced/epidemiology/*etiology/metabolism MH - Environmental Exposure/*adverse effects MH - Environmental Pollutants/*adverse effects MH - Epidemiological Monitoring MH - Female MH - Glucose Transport Proteins, Facilitative/metabolism MH - Herbicides/adverse effects MH - Humans MH - Hydrocarbons, Chlorinated/adverse effects MH - Insulin/metabolism MH - Insulin Secretion MH - Liver/*metabolism MH - Male MH - Pancreas/*metabolism MH - Polychlorinated Biphenyls/adverse effects MH - Polychlorinated Dibenzodioxins/adverse effects MH - Prevalence MH - Protein Binding/drug effects MH - Risk Factors OTO - NOTNLM OT - Diabetes OT - Dioxin OT - Persistent organic pollutants OT - Polychlorinated biphenyls EDAT- 2013/11/23 06:00 MHDA- 2014/11/13 06:00 CRDT- 2013/11/23 06:00 PHST- 2013/08/19 00:00 [received] PHST- 2013/09/26 00:00 [revised] PHST- 2013/09/26 00:00 [accepted] PHST- 2013/11/23 06:00 [entrez] PHST- 2013/11/23 06:00 [pubmed] PHST- 2014/11/13 06:00 [medline] AID - S1262-3636(13)00179-1 [pii] AID - 10.1016/j.diabet.2013.09.006 [doi] PST - ppublish SO - Diabetes Metab. 2014 Feb;40(1):1-14. doi: 10.1016/j.diabet.2013.09.006. Epub 2013 Nov 18.