PMID- 24262865
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20140421
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 116
DP  - 2014 Apr 1
TI  - Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion 
      complexes.
PG  - 612-9
LID - S0927-7765(13)00669-3 [pii]
LID - 10.1016/j.colsurfb.2013.10.029 [doi]
AB  - The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes 
      (CD-IC) with an antibacterial agent (triclosan) was achieved without using any 
      carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were electrospun from 
      highly concentrated (160% CD, w/w) aqueous triclosan/CD-IC suspension by using 
      two types of chemically modified CD; hydroxypropyl-beta-cyclodextrin (HPbetaCD) and 
      hydroxypropyl-gamma-cyclodextrin (HPgammaCD). The morphological characterization of 
      the electrospun triclosan/CD-IC NF by SEM elucidated that the triclosan/HPbetaCD-IC 
      NF and triclosan/HPgammaCD-IC NF were bead-free having average fiber diameter of 520 
      +/- 250 nm and 1,100 +/- 660 nm, respectively. The presence of triclosan and the 
      formation of triclosan/CD-IC within the fiber structure were confirmed by 
      (1)H-NMR, FTIR, XRD, DSC, and TGA studies. The initial 1:1 molar ratio of the 
      triclosan:CD was kept for triclosan/HPbetaCD-IC NF after the electrospinning and 
      whereas 0.7:1 molar ratio was observed for triclosan/HPgammaCD-IC NF and some 
      uncomplexed triclosan was detected suggesting that the complexation efficiency of 
      triclosan with HPgammaCD was lower than that of HPbetaCD. The antibacterial properties 
      of triclosan/CD-IC NF were tested against Gram-negative (Escherichia coli) and 
      Gram-positive (Staphylococcus aureus) bacteria. It was observed that 
      triclosan/HPbetaCD-IC NF and triclosan/HPgammaCD-IC NF showed better antibacterial 
      activity against both bacteria compared to uncomplexed pure triclosan.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Celebioglu, Asli
AU  - Celebioglu A
AD  - Institute of Materials Science & Nanotechnology and UNAM-National Nanotechnology 
      Research Center, Bilkent University, Ankara 06800, Turkey.
FAU - Umu, Ozgun C O
AU  - Umu OC
AD  - Institute of Materials Science & Nanotechnology and UNAM-National Nanotechnology 
      Research Center, Bilkent University, Ankara 06800, Turkey.
FAU - Tekinay, Turgay
AU  - Tekinay T
AD  - Institute of Materials Science & Nanotechnology and UNAM-National Nanotechnology 
      Research Center, Bilkent University, Ankara 06800, Turkey; Gazi University, Life 
      Sciences Application and Research Center, Ankara 06830, Turkey; Gazi University, 
      Polatli Science and Literature Faculty, Ankara 06900, Turkey.
FAU - Uyar, Tamer
AU  - Uyar T
AD  - Institute of Materials Science & Nanotechnology and UNAM-National Nanotechnology 
      Research Center, Bilkent University, Ankara 06800, Turkey. Electronic address: 
      tamer@unam.bilkent.edu.tr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131030
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cyclodextrins)
RN  - 4NM5039Y5X (Triclosan)
SB  - IM
MH  - Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology
MH  - Cyclodextrins/chemistry/*pharmacology
MH  - Electric Conductivity
MH  - Electrodes
MH  - Escherichia coli/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Nanofibers/*chemistry
MH  - Particle Size
MH  - Staphylococcus aureus/*drug effects
MH  - Surface Properties
MH  - Triclosan/chemistry/*pharmacology
MH  - Viscosity
OTO - NOTNLM
OT  - Antibacterial activity
OT  - Cyclodextrin
OT  - Electrospinning
OT  - Inclusion complex
OT  - Nanofibers
OT  - Triclosan
EDAT- 2013/11/23 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/11/23 06:00
PHST- 2013/08/29 00:00 [received]
PHST- 2013/10/11 00:00 [revised]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0927-7765(13)00669-3 [pii]
AID - 10.1016/j.colsurfb.2013.10.029 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2014 Apr 1;116:612-9. doi: 
      10.1016/j.colsurfb.2013.10.029. Epub 2013 Oct 30.