PMID- 24265250
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20220317
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 65
IP  - 10
DP  - 2014 Nov
TI  - Left ventricular systolic and diastolic function in normotensive type 2 diabetic 
      patients with or without autonomic neuropathy: a radionuclide ventriculography 
      study.
PG  - 877-82
LID - 10.1177/0003319713510966 [doi]
AB  - We investigated the relation between diabetic autonomic neuropathy (DAN) and left 
      ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) 
      free of coronary artery disease (CAD) or hypertension. Diabetic autonomic 
      neuropathy was established by >/=2 abnormal autonomic nervous function tests. Left 
      ventricular systolic and diastolic functions were assessed by resting 
      radionuclide ventriculography. Compared with non-DAN patients (n=24), patients 
      with DAN (n=35) had an increased adjusted atrial contribution to ventricular 
      filling (A/V%, 30.1%+/-8.2% vs 26.5%+/-5.1%; P=.031), suggestive of diastolic 
      dysfunction (DD). There were no differences between the 2 groups in peak filling 
      rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac 
      index. Patients with diabetic autonomic neuropathy had an increased heart rate 
      (77.8+/-6.3 vs 69.3+/-3.3 bpm; P<.0001) and a higher rest LV workload (10,072+/-1165 vs 
      8606+/-1075 bpm mm Hg; P<.0001). Patients with DAN T2DM without CAD or hypertension 
      have DD, increased A/V index, and a higher LV working load than non-DAN patients.
CI  - (c) The Author(s) 2013.
FAU - Didangelos, Triantafyllos P
AU  - Didangelos TP
AD  - First Propeudetic Department of Internal Medicine, Diabetes Center, Medical 
      School, Aristotle University of Thessaloniki, "AHEPA'' Hospital, Thessaloniki, 
      Greece didang@med.auth.gr.
FAU - Arsos, Georgios
AU  - Arsos G
AD  - Laboratory of Nuclear Medicine, Medical School, Aristotle University of 
      Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
FAU - Karamitsos, Theodoros
AU  - Karamitsos T
AD  - Department of Cardiovascular Medicine, University of Oxford, John Radcliffe 
      Hospital, United Kingdom.
FAU - Iliadis, Fotios
AU  - Iliadis F
AD  - First Propeudetic Department of Internal Medicine, Diabetes Center, Medical 
      School, Aristotle University of Thessaloniki, "AHEPA'' Hospital, Thessaloniki, 
      Greece.
FAU - Papageorgiou, Athanasios
AU  - Papageorgiou A
AD  - Second Propeudetic Department of Internal Medicine Medical School, Aristotle 
      University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
FAU - Moralidis, Efstratios
AU  - Moralidis E
AD  - Laboratory of Nuclear Medicine, Medical School, Aristotle University of 
      Thessaloniki, "AHEPA" Hospital, Thessaloniki, Greece.
FAU - Athyros, Vasilios
AU  - Athyros V
AD  - Second Propeudetic Department of Internal Medicine Medical School, Aristotle 
      University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20131121
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - Cardiac Output
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Neuropathies/*diagnostic imaging
MH  - Diastole/*physiology
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Radionuclide Ventriculography/*methods
MH  - Systole/*physiology
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - autonomic neuropathy
OT  - diabetes mellitus
OT  - left ventricular function
OT  - radionuclide ventriculography
EDAT- 2013/11/23 06:00
MHDA- 2014/12/19 06:00
CRDT- 2013/11/23 06:00
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - 0003319713510966 [pii]
AID - 10.1177/0003319713510966 [doi]
PST - ppublish
SO  - Angiology. 2014 Nov;65(10):877-82. doi: 10.1177/0003319713510966. Epub 2013 Nov 
      21.