PMID- 24265747
OWN - NLM
STAT- MEDLINE
DCOM- 20140903
LR  - 20240313
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Inverse association of N-terminal pro-B-type natriuretic peptide with metabolic 
      syndrome in patients with congestive heart failure.
PG  - e79096
LID - 10.1371/journal.pone.0079096 [doi]
LID - e79096
AB  - BACKGROUND: Metabolic syndrome has been shown to be associated with lower levels 
      of plasma N-terminal pro-B-type natriuretic peptide (Nt-proBNP) in the general 
      population. We sought to elucidate the relationship between Nt-proBNP and 
      components of metabolic syndrome in patients with congestive heart failure (CHF). 
      METHODS: Fasting blood samples were obtained from 93 patients in our institution. 
      Plasma levels of Nt-proBNP and other biochemical data were measured. The New York 
      Heart Association (NYHA) classification system (I-IV) was used to define the 
      functional capacity of CHF. Metabolic syndrome and its components were defined 
      using diagnostic criteria from the International Diabetes Federation. RESULTS: 
      Forty-nine patients (52.7%) had CHF. There was a positive correlation between 
      plasma Nt-proBNP levels and NYHA functional capacity in CHF patients. Plasma 
      Nt-proBNP levels increased significantly with each increasing NYHA class of the 
      disease. The prevalence of metabolic syndrome in CHF patients was higher than 
      that in patients without CHF. Most importantly, we found that plasma Nt-proBNP 
      levels were lower in CHF patients with metabolic syndrome attributable to inverse 
      relationships between plasma Nt-proBNP and body mass index (beta = -0.297), plasma 
      triglyceride (beta = -0.286) and homeostasis model assessment of insulin resistance 
      (HOMA-IR; beta = -0.346). Fasting glucose to insulin ratio (FGIR, an insulin 
      sensitivity index) was positively associated with plasma Nt-proBNP levels 
      (beta = 0.491), and was the independent predictor of plasma Nt-proBNP levels in CHF 
      patients. CONCLUSIONS: Plasma Nt-proBNP levels are inversely associated with 
      metabolic syndrome in CHF patients. Reduced plasma Nt-proBNP levels in CHF 
      patients may lead to impaired lipolysis and metabolic function, and may 
      contribute to the development of metabolic syndrome in CHF patients.
FAU - Chang, Huai-Ren
AU  - Chang HR
AD  - Division of Cardiology, Department of Internal Medicine, Buddhist Tzu Chi General 
      Hospital, Hualien, Taiwan ; Institute of Medical Sciences, Tzu Chi University, 
      Hualien, Taiwan.
FAU - Hsieh, Jen-Che
AU  - Hsieh JC
FAU - Hsu, Bang-Gee
AU  - Hsu BG
FAU - Wang, Ling-Yi
AU  - Wang LY
FAU - Chen, Michael Yu-Chih
AU  - Chen MY
FAU - Wang, Ji-Hung
AU  - Wang JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131112
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - Fasting/blood
MH  - Female
MH  - Heart Failure/*complications
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Metabolic Syndrome/*blood/*complications
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
PMC - PMC3827135
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/23 06:00
MHDA- 2014/09/04 06:00
PMCR- 2013/11/12
CRDT- 2013/11/23 06:00
PHST- 2013/05/03 00:00 [received]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/09/04 06:00 [medline]
PHST- 2013/11/12 00:00 [pmc-release]
AID - PONE-D-13-18247 [pii]
AID - 10.1371/journal.pone.0079096 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 12;8(11):e79096. doi: 10.1371/journal.pone.0079096. 
      eCollection 2013.