PMID- 24265770
OWN - NLM
STAT- MEDLINE
DCOM- 20140903
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Acute electromyostimulation decreases muscle sympathetic nerve activity in 
      patients with advanced chronic heart failure (EMSICA Study).
PG  - e79438
LID - 10.1371/journal.pone.0079438 [doi]
LID - e79438
AB  - BACKGROUND: Muscle passive contraction of lower limb by neuromuscular 
      electrostimulation (NMES) is frequently used in chronic heart failure (CHF) 
      patients but no data are available concerning its action on sympathetic activity. 
      However, Transcutaneous Electrical Nerve Stimulation (TENS) is able to improve 
      baroreflex in CHF. The primary aim of the present study was to investigate the 
      acute effect of TENS and NMES compared to Sham stimulation on sympathetic 
      overactivity as assessed by Muscle Sympathetic Nerve Activity (MSNA). METHODS: We 
      performed a serie of two parallel, randomized, double blinded and sham controlled 
      protocols in twenty-two CHF patients in New York Heart Association (NYHA) Class 
      III. Half of them performed stimulation by TENS, and the others tested NMES. 
      RESULTS: Compare to Sham stimulation, both TENS and NMES are able to reduce MSNA 
      (63.5 +/- 3.5 vs 69.7 +/- 3.1 bursts / min, p < 0.01 after TENS and 51.6 +/- 3.3 vs 
      56.7 +/- 3.3 bursts / min, p < 0, 01 after NMES). No variation of blood pressure, 
      heart rate or respiratory parameters was observed after stimulation. CONCLUSION: 
      The results suggest that sensory stimulation of lower limbs by electrical device, 
      either TENS or NMES, could inhibit sympathetic outflow directed to legs in CHF 
      patients. These properties could benefits CHF patients and pave the way for a new 
      non-pharmacological approach of CHF.
FAU - Labrunee, Marc
AU  - Labrunee M
AD  - National Institute of Health and Medical ResearchTeam 8 Institut des maladies 
      metaboliques et cardiovasculaires, Toulouse, France ; Faculty of Medicine, 
      University of Toulouse III Paul Sabatier F-31432, Toulouse, France ; Federation 
      of Cardiology, Universitary Hospital of Toulouse, F-31073, Toulouse, France ; 
      Physical Medicine and Rehabilitation unit, Universitary Hospital of Toulouse, 
      F-31073, Toulouse, France.
FAU - Despas, Fabien
AU  - Despas F
FAU - Marque, Philippe
AU  - Marque P
FAU - Guiraud, Thibaut
AU  - Guiraud T
FAU - Galinier, Michel
AU  - Galinier M
FAU - Senard, Jean Michel
AU  - Senard JM
FAU - Pathak, Atul
AU  - Pathak A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131112
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Chronic Disease
MH  - *Electric Stimulation Therapy
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscles/*innervation
MH  - Sympathetic Nervous System/*physiopathology
PMC - PMC3827140
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/23 06:00
MHDA- 2014/09/04 06:00
PMCR- 2013/11/12
CRDT- 2013/11/23 06:00
PHST- 2013/03/21 00:00 [received]
PHST- 2013/09/23 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2014/09/04 06:00 [medline]
PHST- 2013/11/12 00:00 [pmc-release]
AID - PONE-D-13-12550 [pii]
AID - 10.1371/journal.pone.0079438 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 12;8(11):e79438. doi: 10.1371/journal.pone.0079438. 
      eCollection 2013.