PMID- 24266086
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20161128
IS  - 1565-1088 (Print)
VI  - 15
IP  - 10
DP  - 2013 Oct
TI  - Preliminary experience using the transcatheter mitral valve leaflet repair 
      procedure.
PG  - 608-12
AB  - BACKGROUND: Mitral regurgitation (MR) causes increased morbidity and mortality in 
      heart failure patients and is often associated with augmented surgical risk. 
      OBJECTIVES: To assess the preliminary results oftranscatheter mitral valve 
      leaflet repair (TMLR) in a single academic center. METHODS: Data were collected 
      prospectively in the cardiology department of Rabin Medical Center in 2012. Ten 
      consecutive patients (age 69.3 +/- 15.9 years, ejection fraction 36.5 +/- 9.4) 
      who were poor surgical candidates with severe functional MR underwent general 
      anesthesia, followed by trans-septal puncture and a TMLR procedure using the 
      MitraClip device. RESULTS: All 10 patients were considered to have severe 
      functional MR prior to TMLR treatment and were all symptomatic; the mean New York 
      Heart Association (NYHA) class was 3.4 +/- 0.5. The MR severity was 4 +/- 0. 
      There were no immediate complications or failures of the procedure. One patient 
      died on day 5 due to massive gastrointestinal bleeding. Immediately following 
      TMLR all 10 patients showed a profound MR reduction to a mean severity grade of 
      1.6 +/- 0.6. At one month after the procedure, NYHA had decreased to an average 
      of 1.7 +/- 1.0 and was at least grade 2 in all but one patient. After 6 months 
      the MR remained < or = 2 in six of eight patients, with a NYHA average of 1.4 +/- 
      0.5. CONCLUSIONS: The MitraClip procedure was shown to be relatively safe, 
      providing significant clinical benefit to a relatively sick population with 
      severe MR. It is therefore an important alternative to surgery in these high risk 
      patients.
FAU - Perl, Leor
AU  - Perl L
AD  - Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tikva, 
      Israel. l-perl@013.net
FAU - Vaturi, Moti
AU  - Vaturi M
FAU - Assali, Abid
AU  - Assali A
FAU - Shapira, Yaron
AU  - Shapira Y
FAU - Bruckheimer, Elchanan
AU  - Bruckheimer E
FAU - Ben-Gal, Tuvia
AU  - Ben-Gal T
FAU - Vaknin-Assa, Hana
AU  - Vaknin-Assa H
FAU - Sagie, Alik
AU  - Sagie A
FAU - Kornowski, Ran
AU  - Kornowski R
LA  - eng
PT  - Journal Article
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
CIN - Isr Med Assoc J. 2013 Oct;15(10):648-9. PMID: 24266094
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Catheterization
MH  - Cohort Studies
MH  - Echocardiography, Transesophageal
MH  - Female
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mitral Valve Annuloplasty
MH  - Mitral Valve Insufficiency/diagnostic imaging/physiopathology/*surgery
MH  - Stroke Volume
MH  - Treatment Outcome
EDAT- 2013/11/26 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/11/26 06:00
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2013 Oct;15(10):608-12.