PMID- 24266437
OWN - NLM
STAT- MEDLINE
DCOM- 20141009
LR  - 20151119
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Linking)
VI  - 26
IP  - 7
DP  - 2014
TI  - Adherence to antiretroviral therapy and its determinants in children with HIV 
      infection - Experience from Paediatric Centre of Excellence in HIV Care in North 
      India.
PG  - 865-71
LID - 10.1080/09540121.2013.859649 [doi]
AB  - The objective of this study is to assess adherence to antiretroviral therapy 
      (ART) in HIV-infected children using the pill count method, and determine factors 
      leading to adherence failure. Records of 106 children living with HIV (CLHIV) age 
      <15 years and on ART for >6 months were reviewed. Average adherence to ART by 
      pill count method over preceding six months was calculated and re-assessed by 
      3-day recall method. The caregivers of 105 children and one child himself were 
      interviewed about the problems encountered while giving ART. Median age of 
      enrolled children was 104 (inter-quartile range [IQR] 77.3-133.8) months. Median 
      duration of ART was 25 (IQR 16-35) months. The desired adherence level of >95% 
      during six months of review assessed by pill count was achieved in 95.3% 
      children. The 3-day recall method yielded >95% adherence in 99% children (p </= 
      .001). Caregivers of 59 children (56.2%) reported multiple problems while 
      administering drugs. In most instances, problems encountered were related to 
      family/caregivers, the commonest being multiple caregivers, job constraints and 
      death/illness in the family. In conclusion, we found a very high level of 
      adherence to ART in CLHIV. Poor adherence was mainly associated with issues 
      related to the family/caregivers.
FAU - Seth, Anju
AU  - Seth A
AD  - a Department of Pediatrics , Lady Hardinge Medical College , Delhi , India.
FAU - Gupta, Rohini
AU  - Gupta R
FAU - Chandra, Jagdish
AU  - Chandra J
FAU - Maheshwari, Anu
AU  - Maheshwari A
FAU - Kumar, Praveen
AU  - Kumar P
FAU - Aneja, Satinder
AU  - Aneja S
LA  - eng
PT  - Journal Article
DEP - 20131122
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Caregivers
MH  - Child
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - India
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - adherence
OT  - antiretroviral therapy
OT  - children
EDAT- 2013/11/26 06:00
MHDA- 2014/10/10 06:00
CRDT- 2013/11/26 06:00
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2014/10/10 06:00 [medline]
AID - 10.1080/09540121.2013.859649 [doi]
PST - ppublish
SO  - AIDS Care. 2014;26(7):865-71. doi: 10.1080/09540121.2013.859649. Epub 2013 Nov 
      22.