PMID- 24267248
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20181202
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 231
IP  - 2
DP  - 2013 Dec
TI  - Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid 
      atherosclerosis in spinal cord injured subjects.
PG  - 341-5
LID - S0021-9150(13)00602-3 [pii]
LID - 10.1016/j.atherosclerosis.2013.10.005 [doi]
AB  - OBJECTIVE: Previous reports have indicated that subjects with chronic spinal cord 
      injury (SCI) exhibit increased cardiovascular risk compared to able-bodied 
      individuals. This study investigated the relationship between plasmatic oxidized 
      low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue 
      inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the 
      role of physical activity in this regard. METHODS: We studied 42 men with chronic 
      (>/=2 years) SCI [18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 
      able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media 
      thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, 
      non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and 
      TIMP-2 levels were determined by enzyme-linked immunosorbent assay. RESULTS: 
      Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied 
      subjects were statistically similar. Conversely, S-SCI subjects exhibited higher 
      IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 
      and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. 
      Results of bivariate correlation analysis including all injured subjects showed 
      that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and 
      MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the 
      presence or not of physical activity and age showed that OxLDL was associated 
      with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with 
      IMT/diameter ratio in SCI individuals. CONCLUSIONS: Plasmatic OxLDL and MMP-8 
      levels are associated with carotid atherosclerosis and there is an interaction 
      among physical inactivity, atherosclerosis and OxLDL in SCI individuals.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Paim, Layde R
AU  - Paim LR
AD  - Department of Internal Medicine, School of Medical Sciences, University of 
      Campinas, Campinas, SP, Brazil.
FAU - Schreiber, Roberto
AU  - Schreiber R
FAU - Matos-Souza, Jose R
AU  - Matos-Souza JR
FAU - Silva, Anselmo A
AU  - Silva AA
FAU - Campos, Luis F
AU  - Campos LF
FAU - Azevedo, Eliza R
AU  - Azevedo ER
FAU - Alonso, Karina
AU  - Alonso K
FAU - de Rossi, Guilherme
AU  - de Rossi G
FAU - Etchebehere, Mauricio
AU  - Etchebehere M
FAU - Gorla, Jose I
AU  - Gorla JI
FAU - Cliquet, Alberto Jr
AU  - Cliquet A Jr
FAU - Nadruz, Wilson Jr
AU  - Nadruz W Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131015
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (TIMP2 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (oxidized low density lipoprotein)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.34 (MMP8 protein, human)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Carotid Arteries/diagnostic imaging/*pathology
MH  - Carotid Artery Diseases/*blood/complications/pathology
MH  - Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Exercise
MH  - Humans
MH  - Lipoproteins, LDL/*blood
MH  - Male
MH  - Matrix Metalloproteinase 2/blood
MH  - Matrix Metalloproteinase 8/*blood
MH  - Matrix Metalloproteinase 9/blood
MH  - Paraplegia/blood/complications
MH  - Quadriplegia/blood/complications
MH  - Risk
MH  - Sedentary Behavior
MH  - Spinal Cord Injuries/*blood/complications
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Tissue Inhibitor of Metalloproteinase-2/blood
OTO - NOTNLM
OT  - Intima-media thickness
OT  - Metalloproteinases
OT  - Oxidized LDL
OT  - Paraplegia
OT  - Tetraplegia
EDAT- 2013/11/26 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/11/26 06:00
PHST- 2013/07/04 00:00 [received]
PHST- 2013/09/01 00:00 [revised]
PHST- 2013/10/02 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - S0021-9150(13)00602-3 [pii]
AID - 10.1016/j.atherosclerosis.2013.10.005 [doi]
PST - ppublish
SO  - Atherosclerosis. 2013 Dec;231(2):341-5. doi: 
      10.1016/j.atherosclerosis.2013.10.005. Epub 2013 Oct 15.