PMID- 24268194 OWN - NLM STAT- MEDLINE DCOM- 20150420 LR - 20220317 IS - 1873-3727 (Electronic) IS - 0001-8686 (Linking) VI - 207 DP - 2014 May TI - Lipid, protein and poly(NIPAM) coated mesoporous silica nanoparticles for biomedical applications. PG - 155-63 LID - S0001-8686(13)00144-9 [pii] LID - 10.1016/j.cis.2013.10.029 [doi] AB - In the past decade, mesoporous silica nanoparticles (MSNs) as nanocarriers have showed much potential in advanced nanomaterials due to their large surface area and pore volume. Especially, more and more MSNs based nanodevices have been designed as efficient drug delivery systems (DDSs) or biosensors. In this paper, lipid, protein and poly(NIPAM) coated MSNs are reviewed from the preparation, properties and their potential application. We also introduce the preparative methods including physical adsorption, covalent binding and self-assembly on the MSNs' surfaces. Furthermore, the interaction between the aimed cells and these molecular modified MSNs is discussed. We also demonstrate their typical applications, such as photodynamic therapy, bioimaging, controlled release and selective recognition in biomedical field. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Yang, Yang AU - Yang Y AD - National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: yangyang@nanoctr.cn. FAU - Li, Junbai AU - Li J AD - National Center for Nanoscience and Technology, Beijing 100190, China; Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: jbli@iccas.ac.cn. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20131108 PL - Netherlands TA - Adv Colloid Interface Sci JT - Advances in colloid and interface science JID - 8706645 RN - 0 (Acrylic Resins) RN - 0 (Delayed-Action Preparations) RN - 0 (Drug Carriers) RN - 0 (Lipids) RN - 0 (Proteins) RN - 25189-55-3 (poly-N-isopropylacrylamide) RN - 7631-86-9 (Silicon Dioxide) SB - IM MH - Acrylic Resins/*chemistry MH - *Biomedical Technology/trends MH - Chemical Phenomena MH - Delayed-Action Preparations MH - Drug Carriers MH - Humans MH - Image Cytometry/trends MH - Lipids/*chemistry MH - *Models, Chemical MH - Nanoparticles/*chemistry MH - Photochemotherapy/trends MH - Proteins/*chemistry MH - Silicon Dioxide/*chemistry MH - Surface Properties OTO - NOTNLM OT - Biomedical application OT - Lipids OT - Mesoporous silica nanoparticles OT - Poly(NIPAM) OT - Protein EDAT- 2013/11/26 06:00 MHDA- 2015/04/22 06:00 CRDT- 2013/11/26 06:00 PHST- 2013/09/14 00:00 [received] PHST- 2013/10/28 00:00 [revised] PHST- 2013/10/29 00:00 [accepted] PHST- 2013/11/26 06:00 [entrez] PHST- 2013/11/26 06:00 [pubmed] PHST- 2015/04/22 06:00 [medline] AID - S0001-8686(13)00144-9 [pii] AID - 10.1016/j.cis.2013.10.029 [doi] PST - ppublish SO - Adv Colloid Interface Sci. 2014 May;207:155-63. doi: 10.1016/j.cis.2013.10.029. Epub 2013 Nov 8.