PMID- 24269495 OWN - NLM STAT- MEDLINE DCOM- 20140804 LR - 20211021 IS - 1872-7549 (Electronic) IS - 0166-4328 (Print) IS - 0166-4328 (Linking) VI - 259 DP - 2014 Feb 1 TI - Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults. PG - 302-12 LID - S0166-4328(13)00710-9 [pii] LID - 10.1016/j.bbr.2013.11.023 [doi] AB - Convergent evidence from human and non-human animal studies suggests aerobic exercise and increased aerobic capacity may be beneficial for brain health and cognition. It is thought growth factors may mediate this putative relationship, particularly by augmenting plasticity mechanisms in the hippocampus, a brain region critical for learning and memory. Among these factors, glucocorticoids, brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), hormones that have considerable and diverse physiological importance, are thought to effect normal and exercise-induced hippocampal plasticity. Despite these predictions, relatively few published human studies have tested hypotheses that relate exercise and fitness to the hippocampus, and none have considered the potential links to all of these hormonal components. Here we present cross-sectional data from a study of recognition memory; serum BDNF, cortisol, IGF-1, and VEGF levels; and aerobic capacity in healthy young adults. We measured circulating levels of these hormones together with performance on a recognition memory task, and a standard graded treadmill test of aerobic fitness. Regression analyses demonstrated BDNF and aerobic fitness predict recognition memory in an interactive manner. In addition, IGF-1 was positively associated with aerobic fitness, but not with recognition memory. Our results may suggest an exercise adaptation-related change in the BDNF dose-response curve that relates to hippocampal memory. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Whiteman, Andrew S AU - Whiteman AS AD - Department of Psychology and Center for Memory & Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA. FAU - Young, Daniel E AU - Young DE AD - Exercise and Health Sciences Department, College of Nursing and Health Sciences, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA. FAU - He, Xuemei AU - He X AD - Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA. FAU - Chen, Tai C AU - Chen TC AD - Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA. FAU - Wagenaar, Robert C AU - Wagenaar RC AD - Sargent College of Health and Rehabilitation Sciences, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA. FAU - Stern, Chantal E AU - Stern CE AD - Department of Psychology and Center for Memory & Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA. FAU - Schon, Karin AU - Schon K AD - Department of Psychology and Center for Memory & Brain, Boston University, 2 Cummington Mall, Boston, MA 02215, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA. Electronic address: kschon@bu.edu. LA - eng GR - K99 AG036845/AG/NIA NIH HHS/United States GR - UL1 TR000157/TR/NCATS NIH HHS/United States GR - K99AG036845/AG/NIA NIH HHS/United States GR - UL1-TR000157/TR/NCATS NIH HHS/United States GR - R00 AG036845/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20131121 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Vascular Endothelial Growth Factor A) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adolescent MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Exercise/*physiology MH - Female MH - Healthy Volunteers MH - Humans MH - Hydrocortisone/blood MH - Insulin-Like Growth Factor I/metabolism MH - Male MH - Neuropsychological Tests MH - Oxygen Consumption MH - Recognition, Psychology/*physiology MH - Regression Analysis MH - Sex Characteristics MH - Vascular Endothelial Growth Factor A/blood MH - Young Adult PMC - PMC3991014 MID - NIHMS543120 OTO - NOTNLM OT - ACSM OT - American College of Sports Medicine OT - BDNF OT - BMI OT - Cardiovascular fitness OT - DMS OT - ELISA OT - Hippocampus OT - IGF-1 OT - MTL OT - OLS OT - RER OT - RERmax OT - Recognition memory OT - SMT OT - VEGF OT - body mass index OT - brain-derived neurotrophic factor OT - delayed matching-to-sample OT - enzyme-linked immunosorbent assay OT - insulin-like growth factor-1 OT - max OT - maximum observed respiratory exchange ratio OT - medial temporal lobes OT - ordinary least squares OT - peak OT - peak rate of oxygen consumption in mL per kg of body weight per min, measured during test OT - rate of maximal oxygen consumption in mL per kg of body weight per min OT - respiratory exchange ratio OT - subsequent memory test OT - vascular endothelial growth factor EDAT- 2013/11/26 06:00 MHDA- 2014/08/05 06:00 PMCR- 2015/02/01 CRDT- 2013/11/26 06:00 PHST- 2013/07/22 00:00 [received] PHST- 2013/10/16 00:00 [revised] PHST- 2013/11/13 00:00 [accepted] PHST- 2013/11/26 06:00 [entrez] PHST- 2013/11/26 06:00 [pubmed] PHST- 2014/08/05 06:00 [medline] PHST- 2015/02/01 00:00 [pmc-release] AID - S0166-4328(13)00710-9 [pii] AID - 10.1016/j.bbr.2013.11.023 [doi] PST - ppublish SO - Behav Brain Res. 2014 Feb 1;259:302-12. doi: 10.1016/j.bbr.2013.11.023. Epub 2013 Nov 21.