PMID- 24270188
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20211021
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Jan
TI  - Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway.
PG  - 27-9
LID - 10.1038/nn.3591 [doi]
AB  - Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the 
      mesolimbic dopamine reward pathway remain unknown. We report that phasic 
      optogenetic activation of this pathway increases BDNF amounts in the nucleus 
      accumbens (NAc) of socially stressed mice but not of stress-naive mice. This 
      stress gating of BDNF signaling is mediated by corticotrophin-releasing factor 
      (CRF) acting in the NAc. These results unravel a stress context-detecting 
      function of the brain's mesolimbic circuit.
FAU - Walsh, Jessica J
AU  - Walsh JJ
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Friedman, Allyson K
AU  - Friedman AK
AD  - Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Sun, Haosheng
AU  - Sun H
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Heller, Elizabeth A
AU  - Heller EA
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Ku, Stacy M
AU  - Ku SM
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Juarez, Barbara
AU  - Juarez B
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Burnham, Veronica L
AU  - Burnham VL
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Mazei-Robison, Michelle S
AU  - Mazei-Robison MS
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Ferguson, Deveroux
AU  - Ferguson D
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Golden, Sam A
AU  - Golden SA
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Koo, Ja Wook
AU  - Koo JW
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Chaudhury, Dipesh
AU  - Chaudhury D
AD  - Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Christoffel, Daniel J
AU  - Christoffel DJ
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Pomeranz, Lisa
AU  - Pomeranz L
AD  - Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller 
      University, New York, New York, USA.
FAU - Friedman, Jeffrey M
AU  - Friedman JM
AD  - Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller 
      University, New York, New York, USA.
FAU - Russo, Scott J
AU  - Russo SJ
AD  - Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
FAU - Nestler, Eric J
AU  - Nestler EJ
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Han, Ming-Hu
AU  - Han MH
AD  - 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine 
      at Mount Sinai, New York, New York, USA. [2] Fishberg Department of Neuroscience, 
      Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
LA  - eng
GR  - F31 MH095425/MH/NIMH NIH HHS/United States
GR  - R01 MH092306/MH/NIMH NIH HHS/United States
GR  - T32 DA007135/DA/NIDA NIH HHS/United States
GR  - K99 MH094405/MH/NIMH NIH HHS/United States
GR  - T32 MH087004/MH/NIMH NIH HHS/United States
GR  - F32 MH096464/MH/NIMH NIH HHS/United States
GR  - R01 DA014133/DA/NIDA NIH HHS/United States
GR  - T32 MH096678/MH/NIMH NIH HHS/United States
GR  - R01 AA022445/AA/NIAAA NIH HHS/United States
GR  - F31 MH108326/MH/NIMH NIH HHS/United States
GR  - P50 MH096890/MH/NIMH NIH HHS/United States
GR  - R01 MH051399/MH/NIMH NIH HHS/United States
GR  - R01MH092306/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131124
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (ANA 12 compound)
RN  - 0 (Azepines)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Benzamides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Channelrhodopsins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (yellow fluorescent protein, Bacteria)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - 96118-75-1 (corticotropin releasing hormone (9-41))
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Azepines/pharmacology
MH  - Bacterial Proteins/genetics
MH  - Benzamides/pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Channelrhodopsins
MH  - Corticotropin-Releasing Hormone/*metabolism/pharmacology
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Gene Expression Regulation/drug effects/physiology
MH  - Interpersonal Relations
MH  - Luminescent Proteins/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microinjections
MH  - Neurons/*metabolism
MH  - Nucleus Accumbens/cytology/*metabolism
MH  - Optogenetics
MH  - Peptide Fragments/pharmacology
MH  - Photic Stimulation
MH  - Statistics, Nonparametric
MH  - Stress, Psychological/*metabolism/physiopathology
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/genetics
MH  - Ventral Tegmental Area/cytology/*metabolism
PMC - PMC3984932
MID - NIHMS568017
EDAT- 2013/11/26 06:00
MHDA- 2014/02/25 06:00
PMCR- 2014/04/13
CRDT- 2013/11/26 06:00
PHST- 2013/07/09 00:00 [received]
PHST- 2013/10/31 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
PHST- 2014/04/13 00:00 [pmc-release]
AID - nn.3591 [pii]
AID - 10.1038/nn.3591 [doi]
PST - ppublish
SO  - Nat Neurosci. 2014 Jan;17(1):27-9. doi: 10.1038/nn.3591. Epub 2013 Nov 24.