PMID- 24270834
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131125
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 3
IP  - 11
DP  - 2013 Nov 21
TI  - A three-year follow-up on the efficacy of psychosocial interventions for patients 
      with mild dementia and their caregivers: the multicentre, rater-blinded, 
      randomised Danish Alzheimer Intervention Study (DAISY).
PG  - e003584
LID - 10.1136/bmjopen-2013-003584 [doi]
LID - e003584
AB  - OBJECTIVES: To examine the long-term efficacy at the 36-month follow-up of an 
      early psychosocial counselling and support programme lasting 8-12 months for 
      community-dwelling patients with mild Alzheimer's disease and their caregivers. 
      DESIGN: Multicentre, randomised, controlled, rater-blinded trial. SETTING: 
      Primary care and memory clinics in five Danish districts. PARTICIPANTS: 330 
      home-dwelling patients with mild Alzheimer's disease and their primary caregivers 
      (dyads). INTERVENTIONS: Dyads were randomised to receive intervention during the 
      first year after diagnosis. Both intervention and control groups had follow-up 
      visits at 3, 6, 12 and 36 months. MAIN OUTCOME MEASURES: Primary outcomes for the 
      patients assessed at 36-month follow-up were changes from baseline in global 
      cognitive function (Mini-Mental State Examination), depressive symptoms (Cornell 
      Depression Scale) and proxy-rated EuroQoL quality of life on visual analogue 
      scale. The primary outcomes for the caregivers were changes from baseline in 
      depressive symptoms (Geriatric Depression Scale) and self-rated EuroQoL quality 
      of life on a visual analogue scale. The secondary outcome measures for the 
      patient were proxy-rated Quality of Life Scale for Alzheimer's disease (QoL-AD), 
      Neuropsychiatric Inventory-Questionnaire, Alzheimer's disease Cooperative Study 
      Activities of Daily Living Scale, all-cause mortality and nursing home placement. 
      RESULTS: At a 36-month follow-up, 2 years after the completion of the Danish 
      Alzheimer Intervention Study (DAISY), the unadjusted positive effects previously 
      detected at the 12-month follow-up in one patient primary outcome (Cornell 
      depression score) and one patient secondary outcome (proxy-rated QoL-AD) 
      disappeared (Cornell depression score, p=0.93; proxy-rated QoL-AD, p=0.81). No 
      long-term effect of DAISY intervention on any other primary and secondary 
      outcomes was found at the 36-month follow-up. CONCLUSIONS: For patients with very 
      mild Alzheimer's disease and their caregivers, an intensive, multi-component, 
      semitailored psychosocial intervention programme with counselling, education and 
      support during the first year after diagnosis did not show any positive long-term 
      effect on primary and secondary outcomes. TRIAL REGISTRATION: The study was 
      registered in the Clinical Trial Database 
      (http://www.controlled-trials.com/ISRCTN74848736).
FAU - Phung, Kieu T T
AU  - Phung KT
AD  - Memory Disorders Research Group, Danish Dementia Research Centre, Department of 
      Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
FAU - Waldorff, F B
AU  - Waldorff FB
FAU - Buss, D V
AU  - Buss DV
FAU - Eckermann, A
AU  - Eckermann A
FAU - Keiding, N
AU  - Keiding N
FAU - Rishoj, S
AU  - Rishoj S
FAU - Siersma, V
AU  - Siersma V
FAU - Sorensen, J
AU  - Sorensen J
FAU - Sogaard, R
AU  - Sogaard R
FAU - Sorensen, L V
AU  - Sorensen LV
FAU - Vogel, A
AU  - Vogel A
FAU - Waldemar, G
AU  - Waldemar G
LA  - eng
PT  - Journal Article
DEP - 20131121
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3840334
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
PMCR- 2013/11/21
CRDT- 2013/11/26 06:00
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
PHST- 2013/11/21 00:00 [pmc-release]
AID - bmjopen-2013-003584 [pii]
AID - 10.1136/bmjopen-2013-003584 [doi]
PST - epublish
SO  - BMJ Open. 2013 Nov 21;3(11):e003584. doi: 10.1136/bmjopen-2013-003584.