PMID- 24271115
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20211021
IS  - 1558-2531 (Electronic)
IS  - 0018-9294 (Print)
IS  - 0018-9294 (Linking)
VI  - 60
IP  - 12
DP  - 2013 Dec
TI  - An interferometric reflectance imaging sensor for point of care viral 
      diagnostics.
PG  - 3276-83
LID - 10.1109/TBME.2013.2272666 [doi]
AB  - The use of in vitro diagnostic devices is transitioning from the laboratory to 
      the primary care setting to address early disease detection needs. Time critical 
      viral diagnoses are often made without support due to the experimental time 
      required in today's standard tests. Available rapid point of care (POC) viral 
      tests are less reliable, requiring a follow-on confirmatory test before 
      conclusions can be drawn. The development of a reliable POC viral test for the 
      primary care setting would decrease the time for diagnosis leading to a lower 
      chance of transmission and improve recovery. The single particle interferometric 
      reflectance imaging sensor (SP-IRIS) has been shown to be a sensitive and 
      specific-detection platform in serum and whole blood. This paper presents a step 
      towards a POC viral assay through a SP-IRIS prototype with automated data 
      acquisition and analysis and a simple, easy-to-use software interface. Decreasing 
      operation complexity highlights the potential of SP-IRIS as a sensitive and 
      specific POC diagnostic tool. With the integration of a microfluidic cartridge, 
      this automated instrument will allow an untrained user to run a sample-to-answer 
      viral assay in the POC setting.
FAU - Reddington, Alexander P
AU  - Reddington AP
FAU - Trueb, Jacob T
AU  - Trueb JT
FAU - Freedman, David S
AU  - Freedman DS
FAU - Tuysuzoglu, Ahmet
AU  - Tuysuzoglu A
FAU - Daaboul, George G
AU  - Daaboul GG
FAU - Lopez, Carlos A
AU  - Lopez CA
FAU - Karl, W Clem
AU  - Karl WC
FAU - Connor, John H
AU  - Connor JH
FAU - Fawcett, Helen
AU  - Fawcett H
FAU - Unlu, M Selim
AU  - Unlu MS
LA  - eng
GR  - R01 AI096159/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
SB  - IM
MH  - Biosensing Techniques/*instrumentation
MH  - Equipment Design
MH  - Humans
MH  - Interferometry/*instrumentation
MH  - Nanoparticles
MH  - *Point-of-Care Systems
MH  - Software
MH  - Virus Diseases/*diagnosis
MH  - Viruses/*isolation & purification
PMC - PMC4041624
MID - NIHMS589753
EDAT- 2013/11/26 06:00
MHDA- 2014/05/13 06:00
PMCR- 2014/06/02
CRDT- 2013/11/26 06:00
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PHST- 2014/06/02 00:00 [pmc-release]
AID - 10.1109/TBME.2013.2272666 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2013 Dec;60(12):3276-83. doi: 10.1109/TBME.2013.2272666.