PMID- 24272056
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 2
IP  - 3
DP  - 1977 Jun
TI  - Correlation between active rosette formation and delayed cutaneous 
      hypersensitivity in experimental allergic encephalomyelitis.
PG  - 293-302
LID - 10.1007/BF00969359 [doi]
AB  - The effect of encephalitogenic myelin basic protein, BP, on active 
      rosette-forming T cells (ARFC) was compared to that of nonencephalitogenic 
      peptide S42, a synthetic analogue of the tryptophan region of BP. Depression of 
      ARFC by these antigens was reversible within 24 h after a second dose of the 
      antigen into the skin, or after in vitro incubation of lymphocytes with the 
      sensitizing antigen (Ag-ARFC). The ratio of Ag-ARFC to ARFC rose with time 
      following the sensitization but fell shortly before the clinical onset of 
      experimental allergic encephalomyelitis in animals sensitized with BP. In 
      contrast, the Ag-ARFC/ARFC ratios for animals sensitized with peptide S42 reached 
      plateau levels from which they did not drop. The kinetics of the Ag-ARFC/ARFC 
      responses paralleled those for delayed-type skin hypersensitivity (DTH) in the 
      respective animals. The DTH responses rose following sensitization and fell 
      shortly after the appearance of clinical signs of EAE. The results of this study 
      provide in vitro and in vivo evidence for sensitization to myelin basic protein, 
      and focus attention on the ARFC as a measure for an immunologically active cell 
      population which may be quantitated by antigenic stimulation.
FAU - Lee, D H
AU  - Lee DH
AD  - Departments of Surgery and Microbiology, St. Luke's Hospital Center and Columbia 
      University, Amsterdam Avenue at 114th Street, 10025, New York, New York.
FAU - Hashim, G A
AU  - Hashim GA
FAU - Pierce, J C
AU  - Pierce JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
EDAT- 1977/06/01 00:00
MHDA- 1977/06/01 00:01
CRDT- 2013/11/26 06:00
PHST- 1976/12/29 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 1977/06/01 00:00 [pubmed]
PHST- 1977/06/01 00:01 [medline]
AID - 10.1007/BF00969359 [doi]
PST - ppublish
SO  - Neurochem Res. 1977 Jun;2(3):293-302. doi: 10.1007/BF00969359.