PMID- 24272065
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 34
IP  - 5
DP  - 2014 May
TI  - Unexpected association between joint hypermobility syndrome/Ehlers-Danlos 
      syndrome hypermobility type and obsessive-compulsive personality disorder.
PG  - 631-6
LID - 10.1007/s00296-013-2901-2 [doi]
AB  - Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type 
      (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, 
      mainly characterized by joint instability complications, widespread 
      musculoskeletal pain, and minor skin features. In a case-control study, 47 
      consecutive JHS/EDS-HT patients were investigated for the prevalence of 
      psychiatric disorders and compared to 45 healthy controls in a single center. The 
      psychiatric evaluation consisted of structured clinical interview for DSM-IV 
      criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using 
      the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale 
      (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of 
      Functioning Scale (GAF) was used to assess the overall severity of psychological, 
      social, and occupational functions. JHS/EDS-HT patients had significantly higher 
      mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF 
      (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher 
      risk of being affected by any psychiatric disorder, and in particular, a 5.8 
      higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT 
      suffered from obsessive-compulsive personality disorder with an observed 
      prevalence rate of 10.6 % (3.6-23.1). Psychiatric assessment of JHS/EDS-HT 
      patients showed an extremely high prevalence of personality disorders (21 %), and 
      of Axis-I disorders (38 %), mostly depressive. This study did not confirm the 
      previously reported increased rate of panic disorders in JHS/EDS-HT.
FAU - Pasquini, Massimo
AU  - Pasquini M
AD  - Department of Neurology and Psychiatry, Umberto I Hospital, Sapienza University 
      of Rome, Rome, Italy.
FAU - Celletti, Claudia
AU  - Celletti C
FAU - Berardelli, Isabella
AU  - Berardelli I
FAU - Roselli, Valentina
AU  - Roselli V
FAU - Mastroeni, Simona
AU  - Mastroeni S
FAU - Castori, Marco
AU  - Castori M
FAU - Biondi, Massimo
AU  - Biondi M
FAU - Camerota, Filippo
AU  - Camerota F
LA  - eng
PT  - Journal Article
DEP - 20131123
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Compulsive Personality Disorder/diagnosis/*epidemiology/psychology
MH  - Ehlers-Danlos Syndrome/diagnosis/*epidemiology
MH  - Humans
MH  - Joint Instability/diagnosis/*epidemiology
MH  - Male
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Risk Assessment
MH  - Risk Factors
MH  - Rome/epidemiology
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2013/11/26 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/11/26 06:00
PHST- 2012/09/22 00:00 [received]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s00296-013-2901-2 [doi]
PST - ppublish
SO  - Rheumatol Int. 2014 May;34(5):631-6. doi: 10.1007/s00296-013-2901-2. Epub 2013 
      Nov 23.