PMID- 24272318
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20211021
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 264
IP  - 4
DP  - 2014 Jun
TI  - Argyrophilic grain disease as a neurodegenerative substrate in late-onset 
      schizophrenia and delusional disorders.
PG  - 317-31
LID - 10.1007/s00406-013-0472-6 [doi]
AB  - To study the relationship between neurodegenerative diseases including 
      argyrophilic grain disease (AGD) and late-onset schizophrenia and delusional 
      disorders (LOSD; onset >/=40 years of age), we pathologically examined 23 patients 
      with LOSD, 71 age-matched normal controls, and 22 psychiatric disease controls 
      (11 depression, six personality disorder, two bipolar disorders, and three 
      neurotic disorders cases). In all LOSD cases (compared to age-matched normal 
      controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal 
      degeneration (CBD) were 26.1 % (11.3 %), 21.7 % (8.5 %), and 4.3 % (0.0 %), 
      respectively. There was no case of pure Alzheimer's disease (AD). The total 
      frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in 
      normal controls. Argyrophilic grains were significantly more severe in LOSD than 
      in controls, but were almost completely restricted to the limbic system and 
      adjacent temporal cortex. In LOSD patients whose onset occurred at >/=65 years of 
      age (versus age-matched normal controls), the frequencies of LBD and AGD were 
      36.4 % (19.4 %) and 36.4 % (8.3 %), respectively, and AGD was significantly more 
      frequent in LOSD patients than in normal controls. In LOSD patients whose onset 
      occurred at <65 years of age, the frequencies of LBD, AGD, and CBD were 16.7, 
      8.3, and 8.3 %, comparable to those of age-matched normal controls (10.2, 5.1, 
      and 0.0 %). In all psychiatric cases, delusion was significantly more frequent in 
      AGD cases than in cases bearing minimal AD pathology alone. Given these findings, 
      LOSD patients may have heterogeneous pathological backgrounds, and AGD may be 
      associated with the occurrence of LOSD especially after 65 years of age.
FAU - Nagao, Shigeto
AU  - Nagao S
AD  - Department of Neuropsychiatry, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 
      700-8558, Japan.
FAU - Yokota, Osamu
AU  - Yokota O
FAU - Ikeda, Chikako
AU  - Ikeda C
FAU - Takeda, Naoya
AU  - Takeda N
FAU - Ishizu, Hideki
AU  - Ishizu H
FAU - Kuroda, Shigetoshi
AU  - Kuroda S
FAU - Sudo, Koichiro
AU  - Sudo K
FAU - Terada, Seishi
AU  - Terada S
FAU - Murayama, Shigeo
AU  - Murayama S
FAU - Uchitomi, Yosuke
AU  - Uchitomi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131123
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (alpha-Synuclein)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/metabolism/*pathology
MH  - Case-Control Studies
MH  - DNA-Binding Proteins/metabolism
MH  - Female
MH  - Humans
MH  - Intermediate Filaments/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neurodegenerative Diseases/*etiology/*pathology
MH  - Psychotic Disorders/complications/*pathology
MH  - Schizophrenia/*complications/*pathology
MH  - Statistics, Nonparametric
MH  - alpha-Synuclein/metabolism
MH  - tau Proteins/metabolism
EDAT- 2013/11/26 06:00
MHDA- 2015/01/06 06:00
CRDT- 2013/11/26 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/11/05 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1007/s00406-013-0472-6 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2014 Jun;264(4):317-31. doi: 
      10.1007/s00406-013-0472-6. Epub 2013 Nov 23.