PMID- 24273256
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181202
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 33
IP  - 11
DP  - 2013 Nov
TI  - [Effect of Jianpi Qinghua decoctions on interleukin-6 and monocyte chemotactic 
      protein-1 in rats with focal segmental glomurular sclerosis nephropathy: role of 
      the inflammatory signaling pathways].
PG  - 1577-82
AB  - OBJECTIVE: To study the effect of Jianpi Qinghua decoctions in ameliorating 
      kidney fibrosis in rats with focal segmental glomurular sclerosis (FSGS) 
      nephropathy in light of blocking the functions of the inflammatory cells. 
      METHODS: Rat models of FSGS nephropathy were established by left nephrectomy and 
      intravenous injection of adriamycin and treated with Jianpi Qinghua decoction. 
      The renal expressions of interleukin-6 (IL-6), monocyte chemotactic protein 1 
      (MCP-1), and intercellular adhesion molecular-1 (ICAM-1) were detected. RESULTS: 
      Treatment with Jianpi Qinghua decoction, Jianpi decoction, Qinghua decoction, and 
      Niaoduqing particles all significantly lowered renal tubulointerstitial 
      expressions of IL-6 in the model rats (P<0.01). Renal tubulointerstitial MCP-1 
      expressions were all lowered significantly in the rats by treatments with Jianpi 
      Qinghua decoction, Jianpi decoction, QingHua decoctions, and Niaoduqing particles 
      (P<0.01), and Jianpi Qinghua decoction produced a stronger effect than Niaoduqing 
      particles (P<0.05). Jianpi Qinghua decoction, Jianpi decoction, Qinghua 
      decoctions and and Niaoduqing particles all significantly decreased renal 
      tubulointerstitial MCP-1 and ICAM-1 expressions (P<0.01), and Jianpi Qinghua and 
      Qinghua decoctions both showed stronger effects than Niaoduqing particles 
      (P<0.01). Jianpi Qinghua decoctions significantly suppressed the expressions of 
      IL-6, MCP-1, and ICAM-1 and produced stronger effects than Niaoduqing particles 
      on MCP-1 and ICAM-1 expressions. CONCLUSION: Jianpi Qinghua decoctions can 
      ameliorate inflammatory injury and lower the levels of inflammatory factors in 
      rats with FSGS nephropathy, the mechanism of which is associated with inhibiting 
      IL-6 signaling pathway.
FAU - Ma, Xiaohong
AU  - Ma X
AD  - Shuguang Hospital, Shanghai University of Traditional Chinese Medicine/Clinical 
      Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China.E-mail: 
      shandongzhaoshuai@sina.com.
FAU - He, Liqun
AU  - He L
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Glomerulosclerosis, Focal Segmental/*metabolism/pathology
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-6/*metabolism
MH  - Kidney/metabolism/*pathology
MH  - Kidney Tubules/metabolism
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sclerosis
MH  - Signal Transduction/drug effects
EDAT- 2013/11/26 06:00
MHDA- 2016/01/26 06:00
CRDT- 2013/11/26 06:00
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2013 Nov;33(11):1577-82.