PMID- 24273541
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131125
LR  - 20211021
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013
TI  - TWEAK and Fn14 in the Neurovascular Unit.
PG  - 367
LID - 10.3389/fimmu.2013.00367 [doi]
LID - 367
AB  - The neurovascular unit (NVU) is a dynamic structure assembled by endothelial 
      cells (EC), a basement membrane (BM), perivascular astrocytes (PA), pericytes, 
      and surrounding neurons. The NVU regulates the passage of substances and cellular 
      elements from the intravascular space into the brain parenchyma. This function, 
      also known as blood-brain barrier (BBB), is regulated by the integrity of tight 
      junctions proteins between EC, and the interaction between PA and the basal 
      lamina. The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) 
      and its receptor fibroblast growth factor-inducible 14 (Fn14) are abundantly 
      expressed in the NVU. Here we will review data indicating that the interaction 
      between TWEAK and Fn14 in the endothelial cell-BM-astrocyte interface regulates 
      the function of the BBB following an ischemic/hypoxic injury, and that 
      pharmacological inhibition of TWEAK-Fn14 is a promising target for the treatment 
      of patients with neurological diseases that have a direct impact on the structure 
      and function of the NVU.
FAU - Yepes, Manuel
AU  - Yepes M
AD  - Department of Neurology and Center for Neurodegenerative Disease, Emory 
      University School of Medicine , Atlanta, GA , USA ; Department of Neurology, 
      Veterans Affairs Medical Center, Emory University School of Medicine , Atlanta, 
      GA , USA.
LA  - eng
GR  - I01 BX000474/BX/BLRD VA/United States
GR  - R01 NS062073/NS/NINDS NIH HHS/United States
GR  - R01 NS079331/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20131111
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3823030
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cerebral edema
OT  - cerebral ischemia
OT  - fibroblast growth factor-inducible 14
OT  - middle cerebral artery occlusion
OT  - neurovascular unit
OT  - nuclear factor kappa-light-chain-enhancer of activated B cells
OT  - tumor necrosis factor-like weak inducer of apoptosis
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
PMCR- 2013/01/01
CRDT- 2013/11/26 06:00
PHST- 2013/09/14 00:00 [received]
PHST- 2013/10/28 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00367 [doi]
PST - epublish
SO  - Front Immunol. 2013 Nov 11;4:367. doi: 10.3389/fimmu.2013.00367. eCollection 
      2013.