PMID- 24273570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131125
LR  - 20220330
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 9
IP  - 5
DP  - 2013 Oct 31
TI  - Pattern of adverse events of antiepileptic drugs: results of the aESCAPE study in 
      Poland.
PG  - 858-64
LID - 10.5114/aoms.2013.38679 [doi]
AB  - INTRODUCTION: The Adverse Event Scale in Patients With Epilepsy (aESCAPE) 
      European study (NCT00394927) explored and analyzed adverse events (AEs) and 
      reasons for modifying treatment in patients treated with newer and older 
      antiepileptic drugs (AEDs) used in monotherapy or polytherapy. The present 
      analysis concerns the results of patients recruited in Poland. MATERIAL AND 
      METHODS: Multicentre, international, observational, cross-sectional study 
      investigating AEs in patients with epilepsy (aged >/= 4 years), on stable AED 
      treatment with one or two AED(s) for >/= 3 months, using standardized 
      questionnaires completed by a physician during a single study visit. RESULTS: Out 
      of 309 patients, 24.6% were treated exclusively with newer AED(s) in monotherapy 
      or in combination, while 75.4% were treated with older AED(s) or a combination of 
      older and newer AED(s). 60.8% were on monotherapy, and 39.9% on polytherapy. In 
      general, 73.8% of patients reported >/= 1 AE(s). There were no significant 
      differences in the frequency of reported AEs in compared groups. The most common 
      were disturbances in cognitive function (40.5%), psychological problems (36.2%), 
      and sedation (32.7%). Some AEs were found to be more specific for particular 
      types and treatment regimens. Changes in treatment or dose during the study visit 
      occurred in 22.3% of the patients, mainly due to lack of efficacy (10.7%), AEs 
      (5.2%) or absence of seizures (4.5%). CONCLUSIONS: A detailed structured 
      interview revealed high frequency of AEs in patients treated with AEDs. The main 
      reasons for treatment modifications at the study visit were lack of efficacy, 
      adverse events and absence of seizures.
FAU - Chmielewska, Barbara
AU  - Chmielewska B
AD  - Department of Neurology, Medical University of Lublin, Lublin, Poland.
FAU - Lis, Krystyna
AU  - Lis K
FAU - Rejdak, Konrad
AU  - Rejdak K
FAU - Balcerzak, Marcin
AU  - Balcerzak M
FAU - Steinborn, Barbara
AU  - Steinborn B
LA  - eng
PT  - Journal Article
DEP - 20131105
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3832831
OTO - NOTNLM
OT  - Poland
OT  - adverse events
OT  - antiepileptic drugs
OT  - epilepsy
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
PMCR- 2013/10/31
CRDT- 2013/11/26 06:00
PHST- 2011/06/30 00:00 [received]
PHST- 2011/07/24 00:00 [revised]
PHST- 2011/09/04 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
PHST- 2013/10/31 00:00 [pmc-release]
AID - 21680 [pii]
AID - 10.5114/aoms.2013.38679 [doi]
PST - ppublish
SO  - Arch Med Sci. 2013 Oct 31;9(5):858-64. doi: 10.5114/aoms.2013.38679. Epub 2013 
      Nov 5.