PMID- 24273933
OWN - NLM
STAT- MEDLINE
DCOM- 20131218
LR  - 20220408
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 59
IP  - 9-10
DP  - 2013
TI  - The ratio of red cell distribution width to mean corpuscular volume in patients 
      with diabetic ketoacidosis.
PG  - 1099-104
AB  - BACKGROUND: The relationship between erythrocyte parameters and diabetic 
      ketoacidosis (DKA) remains uncertain. This study aimed to investigate the 
      potential role of erythrocyte indices in type 1 diabetes (T1D) patients with DKA. 
      METHODS: This study included 48 patients with T1D, 26 patients with DKA, and 30 
      age- and gender-matched controls. Erythrocyte parameters were measured and 
      evaluated at the time of admission and after treatment. RESULTS: Data were 
      analyzed by One-Way ANOVA Tukey analysis with SPSS software. The DKA patients had 
      higher levels of plasma glucose (28.87 +/- 9.01 mmol/L), HbA1c (13.08 +/- 3.10%), 
      osmotic pressure (332.11 +/- 11.67 mosm/L), red cell distribution width (RDW, 
      41.24 +/- 3.08 fL), and the RDW to mean corpuscular volume (MCV) ratio (47.50 +/- 
      3.70%) compared to non-DKA cases and controls (all p < 0.05). Pearson's 
      correlation test showed that osmolality was positively correlated with plasma 
      glucose (r = 0.699, p < 0.001) and negatively correlated with mean corpuscular 
      hemoglobin concentration (MCHC) (r = -0.409, p = 0.049). Receiver operating 
      characteristic curve analyses demonstrated that the areas under the curves were 
      0.924 for the RDW/MCV ratio and 0.802 for RDW in the ability of reflecting DKA (z 
      = 2.086, p = 0.0369). A logistic regression revealed that the RDW/MCV ratio can 
      act as a robust risk marker for the presence of DKA (OR = 1.548, p = 0.0360, 95% 
      CI: 1.029 - 2.330). The RDW returned to normal, and plasma glucose levels and 
      metabolic acidosis were well controlled following treatment. CONCLUSIONS: The RDW 
      and the RDW/MCV ratio were significantly correlated with DKA. The RDW/MCV ratio 
      can act as a robust biomarker that is more sensitive than RDW in reflecting the 
      presence of DKA.
FAU - Liu, Ding-Sheng
AU  - Liu DS
AD  - Department of Haematology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an 223300, China.
FAU - Jin, Yue
AU  - Jin Y
FAU - Ma, Shao-Gang
AU  - Ma SG
FAU - Bai, Feng
AU  - Bai F
FAU - Xu, Wei
AU  - Xu W
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/complications
MH  - Diabetic Ketoacidosis/*blood
MH  - *Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2013/11/28 06:00
MHDA- 2013/12/19 06:00
CRDT- 2013/11/27 06:00
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2013/12/19 06:00 [medline]
AID - 10.7754/clin.lab.2013.121028 [doi]
PST - ppublish
SO  - Clin Lab. 2013;59(9-10):1099-104. doi: 10.7754/clin.lab.2013.121028.