PMID- 24274373
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 13
DP  - 2013 Nov 25
TI  - Association study of gene polymorphisms and depression with abnormal humor in 
      traditional Uighur medicine.
PG  - 332
LID - 10.1186/1472-6882-13-332 [doi]
AB  - BACKGROUND: According to the humor theory of Traditional Uighur Medicine (TUM), a 
      same disease is classified into different abnormal humor types and corresponding 
      methods are applied to treat the diseases according to the type of abnormal humor 
      characteristics. To date the biological foundation of classification of diseases 
      by humor theory has been little studied and the mechanism of action is still 
      unclear. In the present study, we aimed to investigate the association between 
      some related gene polymorphisms and depression with abnormal humor in TUM. 
      METHODS: 201 cases of depression patients in a Uighur population were divided 
      into two groups as: 107 cases of depression patients with abnormal black bile 
      (ABB), 94 cases of depression patients with none abnormal black bile (nABB), and 
      50 healthy people were served as control group. Venous blood was used to isolate 
      DNA samples, and the polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) technique was used for genotyping of single nucleotide 
      polymorphisms (SNPs). Polymorphisms in the serotonin 2A (5-HT2A) receptor gene, 
      brain derived neurotrophic factor (BDNF), serotonin 1A (5-HT1A) receptor gene 
      were investigated in each groups, respectively. RESULTS: The 5-HT2A A-1438G, 
      5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms showed 
      significant association with ABB. However, no difference between nABB and 
      controls was found for those genotype distribution and allele frequency. 
      Moreover, the T102C and A1438G SNPs in the 5-HT2A receptor gene polymorphisms 
      were in linkage disequilibrium. In addition, the OR associated with the 
      combination of Val66Met-Val/Val genotype plus the presence of -1019C allele was 
      8.393 for ABB compared with controls (OR 8.393; 95% CI 1.807 ~ 38.991; P = 
      0.003). Moreover, the OR associated with the presence of -Met plus -1019C alleles 
      was 12.194 for ABB compared with controls (OR 12.194; 95% CI 1.433 ~ 103.776; P = 
      0.005). The OR associated with the presence of -1438C/C plus Val/Val genotypes 
      was 7.738 for ABB compared with controls (OR 7.738; 95% CI 1.566 ~ 38.241; P = 
      0.005). CONCLUSION: It was concluded that there were significant relationship 
      between the gene polymorphisms and classification of depression with abnormal 
      humor in TUM. The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G 
      gene polymorphisms might predict the incidence of depression with ABB.
FAU - Yusup, Abdiryim
AU  - Yusup A
AD  - Collage of Traditional Uighur Medicine, Xinjiang Medical University, Xinyi Road 
      393, Urumqi, China. halmurat@263.net.
FAU - Upur, Hanzohra
AU  - Upur H
FAU - Abla, Ayimgul
AU  - Abla A
FAU - Upur, Halmurat
AU  - Upur H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131125
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - DNA/analysis/genetics
MH  - Depression/*genetics/physiopathology
MH  - Female
MH  - Genetic Association Studies/methods
MH  - Humans
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Serotonin, 5-HT1A/genetics
MH  - Receptor, Serotonin, 5-HT2A/genetics
PMC - PMC4222500
EDAT- 2013/11/28 06:00
MHDA- 2014/05/14 06:00
PMCR- 2013/11/25
CRDT- 2013/11/27 06:00
PHST- 2013/06/03 00:00 [received]
PHST- 2013/11/21 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
PHST- 2013/11/25 00:00 [pmc-release]
AID - 1472-6882-13-332 [pii]
AID - 10.1186/1472-6882-13-332 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2013 Nov 25;13:332. doi: 10.1186/1472-6882-13-332.