PMID- 24274564
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20171116
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 99
DP  - 2014 Jan
TI  - Synthesis and properties of novel biomimetic and thermo-responsive dextran-based 
      biohybrids.
PG  - 728-35
LID - S0144-8617(13)00912-0 [pii]
LID - 10.1016/j.carbpol.2013.09.020 [doi]
AB  - A new class of biodegradable, biomimetic and thermo-responsive dextran/synthetic 
      glycopolymer biohybrids (dextran-graft-poly(lactobionamidoethyl 
      methacrylate)-block-poly(di(ethylene glycol) methyl ether methacrylate), 
      dextran-g-(PLAMA-b-PDEGMA)), was synthesized by the direct atom transfer radical 
      polymerization (ATRP) of unprotected lactobionamidoethyl methacrylate (LAMA) 
      glycomonomer and di(ethylene glycol) methyl ether methacrylate (DEGMA) monomer. 
      The dextran macroinitiator for ATRP was prepared by partial esterification of the 
      hydroxyl groups of the polysaccharide with 2-bromo-2-methylpropionic acid 
      (BrMPA). The biohybrids containing PDEGMA segments exhibited a lower critical 
      solution temperature (LCST) behavior, which changed from unimers to aggregates in 
      solutions. Moreover, it was demonstrated that these biohybrids had specific 
      biomolecular recognition with ricinus communis agglutinin 120 (RCA(1)(2)(0)) in 
      comparison with bovine serum albumin (BSA). Furthermore, these biohybrids showed 
      good biocompatibility in the cytotoxicity assays. This hopefully provides a 
      platform for targeted drug delivery and studying the biomolecular recognition 
      between sugar and lectin.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Li, Fan
AU  - Li F
AD  - Institute of Materials Science and Engineering, Jilin University, Changchun 
      130023, PR China; State Key Laboratory of Polymer Physics and Chemistry, 
      Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 
      130022, PR China.
FAU - Pei, Danfeng
AU  - Pei D
FAU - Huang, Qingrong
AU  - Huang Q
FAU - Shi, Tongfei
AU  - Shi T
FAU - Zhang, Guo
AU  - Zhang G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130913
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Dextrans)
RN  - 0 (Drug Carriers)
RN  - 0 (Isobutyrates)
RN  - 0 (Methacrylates)
RN  - 0 (Plant Lectins)
RN  - 0 (Ricinus communis agglutinin-1)
RN  - 27432CM55Q (Serum Albumin, Bovine)
SB  - IM
MH  - Animals
MH  - Biomimetics
MH  - Cattle
MH  - Cell Survival/drug effects
MH  - Dextrans/*chemistry
MH  - Drug Carriers/*chemical synthesis/pharmacology
MH  - Hep G2 Cells
MH  - Humans
MH  - Isobutyrates/chemistry
MH  - Magnetic Resonance Spectroscopy
MH  - Methacrylates/*chemistry
MH  - Plant Lectins/*chemistry
MH  - Polymerization
MH  - Serum Albumin, Bovine/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Temperature
OTO - NOTNLM
OT  - Atom transfer radical polymerization
OT  - Biodegradable
OT  - Dextran
OT  - Glycopolymer
OT  - Nanoparticles
OT  - Polysaccharide
EDAT- 2013/11/28 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/11/27 06:00
PHST- 2013/06/13 00:00 [received]
PHST- 2013/08/22 00:00 [revised]
PHST- 2013/09/04 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S0144-8617(13)00912-0 [pii]
AID - 10.1016/j.carbpol.2013.09.020 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2014 Jan;99:728-35. doi: 10.1016/j.carbpol.2013.09.020. Epub 
      2013 Sep 13.