PMID- 24275828
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20220129
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 25
IP  - 5
DP  - 2015 May
TI  - Temporal organization of GABAergic interneurons in the intermediate CA1 
      hippocampus during network oscillations.
PG  - 1228-40
LID - 10.1093/cercor/bht316 [doi]
AB  - Travelling theta oscillations and sharp wave-associated ripples (SWRs) provide 
      temporal structures to neural activity in the CA1 hippocampus. The contribution 
      of rhythm-generating GABAergic interneurons to network timing across the 
      septotemporal CA1 axis remains unknown. We recorded the spike-timing of 
      identified parvalbumin (PV)-expressing basket, axo-axonic, oriens-lacunosum 
      moleculare (O-LM) interneurons, and pyramidal cells in the intermediate CA1 
      (iCA1) of anesthetized rats in relation to simultaneously detected network 
      oscillations in iCA1 and dorsal CA1 (dCA1). Distinct interneuron types were 
      coupled differentially to SWR, and the majority of iCA1 SWR events occurred 
      simultaneously with dCA1 SWR events. In contrast, iCA1 theta oscillations were 
      shifted in time relative to dCA1 theta oscillations. During theta cycles, the 
      highest firing of iCA1 axo-axonic cells was followed by PV-expressing basket 
      cells and subsequently by O-LM together with pyramidal cells, similar to the 
      firing sequence of dCA1 cell types reported previously. However, we observed that 
      this temporal organization of cell types is shifted in time between dCA1 and 
      iCA1, together with the respective shift in theta oscillations. We show that 
      GABAergic activity can be synchronized during SWR but is shifted in time from 
      dCA1 to iCA1 during theta oscillations, highlighting the flexible inhibitory 
      control of excitatory activity across a brain structure.
CI  - (c) The Author 2013. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Forro, Thomas
AU  - Forro T
AD  - Department of Cognitive Neurobiology, Center for Brain Research, Medical 
      University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
FAU - Valenti, Ornella
AU  - Valenti O
AD  - Department of Cognitive Neurobiology, Center for Brain Research, Medical 
      University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
FAU - Lasztoczi, Balint
AU  - Lasztoczi B
AD  - Department of Cognitive Neurobiology, Center for Brain Research, Medical 
      University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria.
FAU - Klausberger, Thomas
AU  - Klausberger T
AD  - Department of Cognitive Neurobiology, Center for Brain Research, Medical 
      University of Vienna, Spitalgasse 4, A-1090, Vienna, Austria Anatomical 
      Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
LA  - eng
GR  - MC_U138197110/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12020/6/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131124
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Parvalbumins)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - CA1 Region, Hippocampal/*cytology/physiology
MH  - GABAergic Neurons/*physiology
MH  - Interneurons/*physiology
MH  - Male
MH  - Parvalbumins/metabolism
MH  - Pyramidal Cells/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Theta Rhythm/*physiology
OTO - NOTNLM
OT  - GABAergic interneurons
OT  - intermediate CA1 hippocampus
OT  - sharp wave ripples
OT  - theta oscillations
EDAT- 2013/11/28 06:00
MHDA- 2016/01/20 06:00
CRDT- 2013/11/27 06:00
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - bht316 [pii]
AID - 10.1093/cercor/bht316 [doi]
PST - ppublish
SO  - Cereb Cortex. 2015 May;25(5):1228-40. doi: 10.1093/cercor/bht316. Epub 2013 Nov 
      24.