PMID- 2427805
OWN - NLM
STAT- MEDLINE
DCOM- 19860929
LR  - 20131121
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 8
IP  - 4
DP  - 1986 Jul-Aug
TI  - Vasopressin: mechanism of central cardiovascular action in conscious rats.
PG  - 689-96
AB  - Arginine vasopressin (AVP) and AVP binding sites have been localized in brain 
      areas involved in cardiovascular control. To elucidate the mechanisms by which 
      brain AVP may participate in central blood pressure regulation, we investigated 
      the effects of central AVP receptor stimulation on mean arterial pressure (MAP), 
      heart rate (HR), efferent splanchnic nerve (SpNA), and renal nerve activity (RNA) 
      in conscious chronically instrumented rats. Intracerebroventricular (i.c.v.) 
      injections of AVP (1-100 ng) produced dose-dependent increases in MAP together 
      with marked increases in HR, SpNA, and RNA. The pressor responses were inhibited 
      by peripheral alpha-adrenoceptor blockade with i.v. phentolamine. In contrast, 
      the pressor responses to either i.v. or intracarotid injections of AVP were 
      accompanied by baroreceptor reflex (BRR)-mediated decreases in HR and SpNA. 
      Central (i.c.v.) pretreatment with d(CH2)5AVP, a V1-AVP receptor antagonist, 
      completely abolished the responses to i.c.v. but not to i.v. AVP. The same 
      antagonist had no effect on the responses to i.c.v. angiotensin II. Our results 
      demonstrate that: (a) central AVP overrides the BRR by sympathetic stimulation, 
      whereas blood-borne AVP activates the BRR; (b) specific AVP receptors in the 
      brain probably of the V1-subtype are involved in the central pressor responses to 
      AVP; (c) the central pressor actions of AVP are transmitted to the periphery by 
      stimulation of the sympathetic nervous system. We conclude that brain AVP may 
      contribute to central cardiovascular control by modulating the sympathetic 
      outflow to the periphery.
FAU - Rohmeiss, P
AU  - Rohmeiss P
FAU - Becker, H
AU  - Becker H
FAU - Dietrich, R
AU  - Dietrich R
FAU - Luft, F
AU  - Luft F
FAU - Unger, T
AU  - Unger T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Receptors, Vasopressin)
RN  - 11128-99-7 (Angiotensin II)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Arginine Vasopressin/administration & dosage/antagonists & 
      inhibitors/*pharmacology
MH  - Brain/*drug effects
MH  - Hemodynamics/*drug effects
MH  - Injections, Intra-Arterial
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Kidney/innervation
MH  - Male
MH  - Phentolamine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Angiotensin/physiology
MH  - *Receptors, Vasopressin
MH  - Splanchnic Nerves/drug effects
MH  - Sympathetic Nervous System/*drug effects
EDAT- 1986/07/01 00:00
MHDA- 1986/07/01 00:01
CRDT- 1986/07/01 00:00
PHST- 1986/07/01 00:00 [pubmed]
PHST- 1986/07/01 00:01 [medline]
PHST- 1986/07/01 00:00 [entrez]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):689-96.