PMID- 24278229
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20220317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Association between telomere length and type 2 diabetes mellitus: a 
      meta-analysis.
PG  - e79993
LID - 10.1371/journal.pone.0079993 [doi]
LID - e79993
AB  - BACKGROUND: Several epidemiological studies have examined the association between 
      shortened telomere length and type 2 diabetes mellitus (T2DM), while the results 
      remained conflicting. We conducted a meta-analysis to derive a more precise 
      estimation of the relationship between them. METHODS: We systematically reviewed 
      the databases of PubMed, EMBASE, and Web of Science for all studies on the 
      association between telomere length and T2DM. We conducted this study assessed by 
      STATA 11.0. Data were summarized using random-effects or fixed-effects 
      meta-analysis. The heterogeneity and publication bias among studies were examined 
      by using chi(2)-based Q statistic test and Egger's test, respectively. RESULTS: 
      Nine cohorts consisting of 5759 cases and 6518 controls were selected into the 
      meta-analysis. The results indicated that shortened telomere length was 
      significantly associated with T2DM risk (OR: 1.291; 95% CI: 1.112, 1.498; 
      P<0.001) with heterogeneity (I(2) = 71.6%). When three cohorts responsible for 
      the heterogeneity were excluded, the pooled OR for the remaining cohorts 
      indicated a significant association between shortened telomere length and T2DM 
      (OR: 1.117; 95% CI: 1.002, 1.246; P = 0.045) without heterogeneity. CONCLUSION: 
      We found a statistically significant association between shortened telomere 
      length and T2DM.
FAU - Zhao, Jinzhao
AU  - Zhao J
AD  - Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      China.
FAU - Miao, Kun
AU  - Miao K
FAU - Wang, Haoran
AU  - Wang H
FAU - Ding, Hu
AU  - Ding H
FAU - Wang, Dao Wen
AU  - Wang DW
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20131121
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Humans
MH  - *Telomere
PMC - PMC3836967
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/28 06:00
MHDA- 2014/09/24 06:00
PMCR- 2013/11/21
CRDT- 2013/11/27 06:00
PHST- 2013/01/23 00:00 [received]
PHST- 2013/10/04 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
PHST- 2013/11/21 00:00 [pmc-release]
AID - PONE-D-13-03689 [pii]
AID - 10.1371/journal.pone.0079993 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 21;8(11):e79993. doi: 10.1371/journal.pone.0079993. 
      eCollection 2013.