PMID- 24278457
OWN - NLM
STAT- MEDLINE
DCOM- 20140805
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Reduced levels of NR1 and NR2A with depression-like behavior in different brain 
      regions in prenatally stressed juvenile offspring.
PG  - e81775
LID - 10.1371/journal.pone.0081775 [doi]
LID - e81775
AB  - Adolescence is a time of continued brain maturation, particularly in limbic and 
      cortical regions, which undoubtedly plays a role in the physiological and 
      emotional changes. Juvenile rats repeatedly exposed to prenatal stress (PS) 
      exhibit behavioral features often observed in neuropsychiatric disorders 
      including depression. However, to date the underlying neurological mechanisms are 
      still unclear. In the current study, juvenile offspring rats whose mothers were 
      exposed to PS were evaluated for depression-related behaviors in open field and 
      sucrose preference test. NMDA receptor subunits NR1 and NR2A in the hippocampus, 
      frontal cortex and striatum were assayed by western blotting. The results 
      indicated that PS resulted in several behavioral anomalies in the OFT and sucrose 
      preference test. Moreover, reduced levels of NMDA receptor subunits NR1 and NR2A 
      in the hippocampus, and NR1 in prefrontal cortex and striatum of prenatally 
      stressed juvenile offspring were found. Treatment with MK-801 to pregnant dams 
      could prevent all those changes in the juvenile offspring. Collectivity, these 
      data support the argument that PS to pregnant dams could induce depression-like 
      behavior, which may be involved with abnormal expression of NR1 and NR2A in 
      specific brain regions, and MK-801 may have antidepressant-like effects on the 
      juvenile offspring.
FAU - Sun, Hongli
AU  - Sun H
AD  - Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, 
      Shaanxi, China.
FAU - Guan, Lixia
AU  - Guan L
FAU - Zhu, Zhongliang
AU  - Zhu Z
FAU - Li, Hui
AU  - Li H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131120
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 57-50-1 (Sucrose)
RN  - VH92ICR8HX (N-methyl D-aspartate receptor subtype 2A)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Blotting, Western
MH  - Body Weight
MH  - Brain/*metabolism/physiopathology
MH  - Depression/*metabolism/physiopathology
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - *Stress, Physiological
MH  - Sucrose/administration & dosage
PMC - PMC3835745
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/28 06:00
MHDA- 2014/08/06 06:00
PMCR- 2013/11/20
CRDT- 2013/11/27 06:00
PHST- 2013/09/09 00:00 [received]
PHST- 2013/10/26 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/08/06 06:00 [medline]
PHST- 2013/11/20 00:00 [pmc-release]
AID - PONE-D-13-37163 [pii]
AID - 10.1371/journal.pone.0081775 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 20;8(11):e81775. doi: 10.1371/journal.pone.0081775. 
      eCollection 2013.