PMID- 24278867
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 9
IP  - 2
DP  - 2013 Apr
TI  - Sudden detraining deteriorates swimming training-induced enhancement of 
      short-term and spatial learning memories in mice.
PG  - 243-9
LID - 10.12965/jer.130006 [doi]
AB  - In the present study, we investigated the effect of swimming training and sudden 
      detraining on learning ability and spatial memory capability and on neurogenesis 
      and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of 
      mice. Male ICR mice were randomly assigned into three groups (n= 15 in each 
      group): the control group, the swimming training group, and the detraining group. 
      The mice in the swimming training group were made to swim (6 days/week, 60 
      min/day) for 8 weeks. The mice in the detraining group were accomplished the same 
      swimming program for 4 weeks and then discontinued exercise for 4 weeks. In the 
      present results, enhanced short-term and spatial learning memories and increased 
      hippocampal neurogenesis and BDNF expression were observed in the mice of the 
      swimming training group. In contrast, decreased short-term and spatial learning 
      memories were observed in the mice of the swimming detraining group compared to 
      the control level. Hippocampal neurogenesis and BDNF expression were also 
      decreased in the mice of the detraining group near to the control level. Here in 
      this study, we suggest that sudden cessation of exercise training might bring 
      decline of the brain functions.
FAU - Kim, You-Mi
AU  - Kim YM
AD  - Department of Sports Science, College of Life Science and Nano Technology, Hannam 
      University, Daejeon, Korea.
FAU - Ji, Eun-Sang
AU  - Ji ES
FAU - Yoon, Sung-Jin
AU  - Yoon SJ
FAU - Yoon, Jin-Hwan
AU  - Yoon JH
LA  - eng
PT  - Journal Article
DEP - 20130425
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC3836522
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Detraining
OT  - Neurogenesis
OT  - Short-term memory
OT  - Spatial learning memory
OT  - Training
EDAT- 2013/11/28 06:00
MHDA- 2013/11/28 06:01
PMCR- 2013/04/25
CRDT- 2013/11/27 06:00
PHST- 2013/03/05 00:00 [received]
PHST- 2013/03/12 00:00 [revised]
PHST- 2013/03/30 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2013/11/28 06:01 [medline]
PHST- 2013/04/25 00:00 [pmc-release]
AID - jer-9-2-6-243_249 [pii]
AID - 10.12965/jer.130006 [doi]
PST - ppublish
SO  - J Exerc Rehabil. 2013 Apr;9(2):243-9. doi: 10.12965/jer.130006. Epub 2013 Apr 25.