PMID- 24278883
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 9
IP  - 3
DP  - 2013
TI  - Treadmill exercise inhibits apoptotic neuronal cell death with suppressed 
      vascular endothelial growth factor expression in the retinas of the diabetic 
      rats.
PG  - 348-53
LID - 10.12965/jer.130043 [doi]
AB  - Diabetic retinopathy is one of the most important microvascular complications in 
      diabetes, and it is the major cause of visual loss. Physical exercise is known to 
      ameliorate the symptoms of metabolic syndromes such as diabetic mellitus. In the 
      present study, we investigated the effects of treadmill exercise on vascular 
      endothelial growth factor (VEGF) expression and apoptotic cell death in the 
      retinas of streptozotocin (STZ)-induced diabetic rats. The male Sprague-Dawley 
      rats were randomly divided into three groups (n = 10 in each group): control 
      group, STZ-induce diabetes group, STZ-induced diabetes and treadmill exercise 
      group. To induce diabetes in the experimental animals, a single intraperitioneal 
      injection of STZ (50 mg/kg) was given to each animal. The rats in the exercise 
      group were forced to run on a motorized treadmill for 30 min once a day during 1 
      week starting 6 weeks after STZ injection. In the present results, VEGF 
      expression in the retinas was increased by induction of diabetes. The numbers of 
      caspase-3-positive and terminal deoxynucleotidyl transferase-mediated dUTP nick 
      end labeling (TUNEL)-positive cells in the retinas were also enhanced by 
      induction of diabetes. Treadmill exercise significantly decreased VEGF expression 
      and suppressed the number of TUNEL-positive and caspase-3-positive cells in the 
      retinas of diabetic rats. In the present study, we have shown that treadmill 
      exercise might alleviate the progression of diabetic retinopathy through 
      suppressing VEGF expression and apoptotic cell death in the retinas of the 
      diabetic rats.
FAU - Ji, Eun-Sang
AU  - Ji ES
AD  - Department of Sport & Health Science, College of Natural Science, Sangmyung 
      University, Seoul, Korea.
FAU - Ko, Il-Gyu
AU  - Ko IG
FAU - Cho, Jung-Wan
AU  - Cho JW
FAU - Davis, Ronald W
AU  - Davis RW
FAU - Hwang, Gwang-Yon
AU  - Hwang GY
FAU - Jee, Yong-Seok
AU  - Jee YS
FAU - Lim, Baek-Vin
AU  - Lim BV
LA  - eng
PT  - Journal Article
DEP - 20130630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC3836530
OTO - NOTNLM
OT  - Apoptosis
OT  - Diabetic retinopathy
OT  - Streptozotocin
OT  - Vascular endothelial growth factor
EDAT- 2013/11/28 06:00
MHDA- 2013/11/28 06:01
PMCR- 2013/07/30
CRDT- 2013/11/27 06:00
PHST- 2013/06/07 00:00 [received]
PHST- 2013/06/14 00:00 [revised]
PHST- 2013/06/23 00:00 [accepted]
PHST- 2013/11/27 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2013/11/28 06:01 [medline]
PHST- 2013/07/30 00:00 [pmc-release]
AID - jer-9-3-3-348_353 [pii]
AID - 10.12965/jer.130043 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2013 Jun 30;9(3):348-53. doi: 10.12965/jer.130043. eCollection 
      2013.