PMID- 24280707
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20131216
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 68
IP  - 4
DP  - 2013
TI  - Maternal separation induces alterations in reversal learning and brain-derived 
      neurotrophic factor expression in adult rats.
PG  - 243-9
LID - 10.1159/000356188 [doi]
AB  - AIMS: Early postnatal maternal and/or sibling separation (MS) can play an 
      important role in the development of psychopathologies during ontogeny. The 
      purpose of the present study is to investigate the effects of repeated MS on the 
      cognitive and brain-derived neurotrophic factor (BDNF) function of rats. METHODS: 
      We investigated the effects of repeated MS that lasted 3 h/day during postnatal 
      days 1-21 on spatial learning and reversal learning in Morris water maze tests in 
      male rats. The rats were tested in 4 trials. Moreover, we examined the effects of 
      MS on BDNF protein expression in the medial prefrontal cortex (mPFC), the nucleus 
      accumbens, and the hippocampus via immunohistochemistry measurements. RESULTS: We 
      found that repeated MS modestly disrupted reversal learning performance in the 
      Morris water maze and decreased BDNF protein expression in the mPFC. CONCLUSION: 
      The present study enhances our understanding of the neurobiological and 
      behavioral consequences of repeated episodes of MS in rats to some degree.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Xue, Xiaofang
AU  - Xue X
AD  - Department of Psychology, Peking University, Beijing, China.
FAU - Shao, Shuang
AU  - Shao S
FAU - Wang, Weiwen
AU  - Wang W
FAU - Shao, Feng
AU  - Shao F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131121
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Hippocampus/metabolism
MH  - Male
MH  - *Maternal Deprivation
MH  - Maze Learning
MH  - Nucleus Accumbens/metabolism
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - *Reversal Learning
EDAT- 2013/11/28 06:00
MHDA- 2014/10/11 06:00
CRDT- 2013/11/28 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/11/28 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 000356188 [pii]
AID - 10.1159/000356188 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;68(4):243-9. doi: 10.1159/000356188. Epub 2013 Nov 21.