PMID- 24281119
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131127
LR  - 20211021
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Jun 21
TI  - The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling 
      in prostate cancer cells.
PG  - 1354-78
LID - 10.3390/cancers2021354 [doi]
AB  - Reactive oxygen species (ROS) signaling has recently sparked a surge of interest 
      as being the molecular underpinning for cancer cell survival, but the precise 
      mechanisms involved have not been completely elucidated. This review covers the 
      possible roles of two ROS-induced transcription factors, Nrf1 and Nrf2, and the 
      antioxidant proteins peroxiredoxin-1 (Prx-1) and Thioredoxin-1 (Txn-1) in 
      modulating AR expression and signaling in aggressive prostate cancer (PCa) cells. 
      In androgen independent (AI) C4-2B cells, in comparison to the parental androgen 
      dependent (AD) LNCaP cells, we present evidence of high Nrf1 and Prx-1 expression 
      and low Nrf2 expression in these aggressive PCa cells. Furthermore, in DHT 
      treated C4-2B cells, increased expression of the p65 (active) isoform of Nrf1 
      correlated with enhanced AR transactivation. Our findings implicate a crucial 
      balance of Nrf1 and Nrf2 signaling in regulating AR activity in AI-PCa cells. 
      Here we will discuss how understanding the mechanisms by which oxidative stress 
      may affect AR signaling may aid in developing novel therapies for AI-PCa.
FAU - Schultz, Michelle A
AU  - Schultz MA
AD  - Department of Pharmacology, Tulane University Medical Center, 1430 Tulane Avenue, 
      New Orleans, LA 70112, USA. dmondal@tulane.edu.
FAU - Abdel-Mageed, Asim B
AU  - Abdel-Mageed AB
FAU - Mondal, Debasis
AU  - Mondal D
LA  - eng
PT  - Journal Article
DEP - 20100621
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC3835133
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/06/21
CRDT- 2013/11/28 06:00
PHST- 2010/06/07 00:00 [received]
PHST- 2010/06/18 00:00 [revised]
PHST- 2010/06/21 00:00 [accepted]
PHST- 2013/11/28 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/06/21 00:00 [pmc-release]
AID - cancers2021354 [pii]
AID - cancers-02-01354 [pii]
AID - 10.3390/cancers2021354 [doi]
PST - epublish
SO  - Cancers (Basel). 2010 Jun 21;2(2):1354-78. doi: 10.3390/cancers2021354.