PMID- 24282579
OWN - NLM
STAT- MEDLINE
DCOM- 20140805
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 11
DP  - 2013
TI  - Breed-specific hematological phenotypes in the dog: a natural resource for the 
      genetic dissection of hematological parameters in a mammalian species.
PG  - e81288
LID - 10.1371/journal.pone.0081288 [doi]
LID - e81288
AB  - Remarkably little has been published on hematological phenotypes of the domestic 
      dog, the most polymorphic species on the planet. Information on the signalment 
      and complete blood cell count of all dogs with normal red and white blood cell 
      parameters judged by existing reference intervals was extracted from a veterinary 
      database. Normal hematological profiles were available for 6046 dogs, 5447 of 
      which also had machine platelet concentrations within the reference interval. 
      Seventy-five pure breeds plus a mixed breed control group were represented by 10 
      or more dogs. All measured parameters except mean corpuscular hemoglobin 
      concentration (MCHC) varied with age. Concentrations of white blood cells (WBCs), 
      neutrophils, monocytes, lymphocytes, eosinophils and platelets, but not red blood 
      cell parameters, all varied with sex. Neutering status had an impact on 
      hemoglobin concentration, mean corpuscular hemoglobin (MCH), MCHC, and 
      concentrations of WBCs, neutrophils, monocytes, lymphocytes and platelets. 
      Principal component analysis of hematological data revealed 37 pure breeds with 
      distinctive phenotypes. Furthermore, all hematological parameters except MCHC 
      showed significant differences between specific individual breeds and the mixed 
      breed group. Twenty-nine breeds had distinctive phenotypes when assessed in this 
      way, of which 19 had already been identified by principal component analysis. 
      Tentative breed-specific reference intervals were generated for breeds with a 
      distinctive phenotype identified by comparative analysis. This study represents 
      the first large-scale analysis of hematological phenotypes in the dog and 
      underlines the important potential of this species in the elucidation of genetic 
      determinants of hematological traits, triangulating phenotype, breed and genetic 
      predisposition.
FAU - Lawrence, Jennifer
AU  - Lawrence J
AD  - Department of Clinical Sciences and Services, Regulatory T Cell Laboratory, The 
      Royal Veterinary College, Camden Campus, Royal College Street, London, United 
      Kingdom.
FAU - Chang, Yu-Mei Ruby
AU  - Chang YM
FAU - Szladovits, Balazs
AU  - Szladovits B
FAU - Davison, Lucy J
AU  - Davison LJ
FAU - Garden, Oliver A
AU  - Garden OA
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20131125
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - *Blood Cell Count
MH  - Dogs/*genetics
MH  - Phenotype
MH  - Principal Component Analysis
MH  - Species Specificity
PMC - PMC3840015
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/28 06:00
MHDA- 2014/08/06 06:00
PMCR- 2013/11/25
CRDT- 2013/11/28 06:00
PHST- 2013/08/06 00:00 [received]
PHST- 2013/10/20 00:00 [accepted]
PHST- 2013/11/28 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/08/06 06:00 [medline]
PHST- 2013/11/25 00:00 [pmc-release]
AID - PONE-D-13-32917 [pii]
AID - 10.1371/journal.pone.0081288 [doi]
PST - epublish
SO  - PLoS One. 2013 Nov 25;8(11):e81288. doi: 10.1371/journal.pone.0081288. 
      eCollection 2013.