PMID- 24282805
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131127
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 9
IP  - 5
DP  - 2013
TI  - Short-term treadmill exercise preserves sensory-motor function through inhibiting 
      apoptosis in the hippocampus of hypoxic ischemia injury rat pups.
PG  - 457-62
LID - 10.12965/jer.130055 [doi]
AB  - Perinatal hypoxic ischemia injury is a common cause of morbidity and mortality in 
      neonates. Physical exercise may ameliorate neurological impairment by impeding 
      neuronal loss following various brain insults. In the present study, the effect 
      of treadmill exercise on sensory-motor function in relation with hippocampal 
      apoptosis following hypoxic ischemia brain injury was investigated. Sensory-motor 
      function was determined by walking initiation test and apoptosis was detected by 
      terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      staining and caspase-3 immunohistochemistry. On postnatal 7 day, left common 
      carotid artery of the neonatal rats was ligated for two hours and then the 
      neonatal rats were exposed to hypoxia conditions for one hour. The rat pups in 
      the exercise groups were forced to run on a motorized treadmill for 30 min once a 
      day for 10 days, starting 22 days after induction of hypoxic ischemia brain 
      injury. Hypoxic ischemia caused sensory-motor disturbance with enhancement of 
      apoptosis in the hippocampus. Short-term treadmill exercise suppressed hypoxic 
      ischemia injury-induced apoptosis in the hippocampus, and preserved sensory-motor 
      function of hypoxic ischemia injury rat pups.
FAU - Choi, Jun-Ho
AU  - Choi JH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Tae-Soo
AU  - Kim TS
FAU - Park, Joon-Ki
AU  - Park JK
FAU - Sim, Young-Je
AU  - Sim YJ
FAU - Kim, Kijeong
AU  - Kim K
FAU - Lee, Sam-Jun
AU  - Lee SJ
LA  - eng
PT  - Journal Article
DEP - 20131031
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC3836552
OTO - NOTNLM
OT  - Apoptosis
OT  - Hippocampus
OT  - Hypoxic ischemia
OT  - Sensory-motor function
OT  - Short-term treadmill exercise
EDAT- 2013/11/28 06:00
MHDA- 2013/11/28 06:01
PMCR- 2013/10/31
CRDT- 2013/11/28 06:00
PHST- 2013/08/01 00:00 [received]
PHST- 2013/08/23 00:00 [revised]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/11/28 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2013/11/28 06:01 [medline]
PHST- 2013/10/31 00:00 [pmc-release]
AID - jer-9-5-457-3 [pii]
AID - 10.12965/jer.130055 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2013 Oct 31;9(5):457-62. doi: 10.12965/jer.130055. eCollection 
      2013.