PMID- 24282819
OWN - NLM
STAT- MEDLINE
DCOM- 20140611
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2013
DP  - 2013
TI  - Folic acid-chitosan conjugated nanoparticles for improving tumor-targeted drug 
      delivery.
PG  - 723158
LID - 10.1155/2013/723158 [doi]
LID - 723158
AB  - OBJECTIVE: To prepare folic acid-chitosan conjugated nanoparticles (FA-CS NPs) 
      and evaluate their targeting specificity on tumor cells. METHODS: Chitosan (CS) 
      NPs were prepared by ionic cross linking method, and folic acid (FA) was 
      conjugated with CS NPs by electrostatic interaction. The properties of NPs were 
      investigated, and doxorubicin hydrochloride (Dox) as a model drug was 
      encapsulated for investigating drug release pattern in vitro. The cytotoxicity 
      and cellular uptake of FA-CS NPs were also investigated. RESULTS: The results 
      reveal that the obtained FA-CS NPs were monodisperse nanoparticles with suitable 
      average size and positive surface charge. Dox was easily loaded into FA-CS NPs, 
      and the release pattern showed a long and biphasic drug release. Noticeable 
      phagocytosis effect was observed in the presence of rhodamine B-labeled FA-CSNPs 
      when incubating with the folate receptor-positive SMMC-7221 cells. CONCLUSION: 
      Compared with the unmodified CS NPs, FA-CS NPs showed much higher cell uptaking 
      ability due to the known folate-receptor mediated endocytosis. FA-CS NPs provide 
      a potential way to enhance the using efficiency of antitumor drug by folate 
      receptor mediated targeting delivery.
FAU - Song, Huijuan
AU  - Song H
AD  - Central Laboratory for Science and Technology, Liaoning Medical University, 
      Jinzhou 121000, China.
FAU - Su, Chang
AU  - Su C
FAU - Cui, Wenyu
AU  - Cui W
FAU - Zhu, Bingya
AU  - Zhu B
FAU - Liu, Liwei
AU  - Liu L
FAU - Chen, Zhenhua
AU  - Chen Z
FAU - Zhao, Liang
AU  - Zhao L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131026
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Folic Acid Transporters)
RN  - 0 (Neoplasm Proteins)
RN  - 80168379AG (Doxorubicin)
RN  - 9012-76-4 (Chitosan)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - *Antibiotics, Antineoplastic/chemistry/pharmacokinetics/pharmacology
MH  - Cell Line, Tumor
MH  - *Chitosan/chemistry/pharmacokinetics/pharmacology
MH  - *Doxorubicin/chemistry/pharmacokinetics/pharmacology
MH  - Drug Delivery Systems
MH  - *Folic Acid/chemistry/pharmacokinetics/pharmacology
MH  - Folic Acid Transporters/agonists/metabolism
MH  - Humans
MH  - Nanoparticles/*chemistry
MH  - Neoplasm Proteins/agonists/metabolism
MH  - Neoplasms/*drug therapy/metabolism/pathology
MH  - Phagocytosis/drug effects
PMC - PMC3825055
EDAT- 2013/11/28 06:00
MHDA- 2014/06/12 06:00
PMCR- 2013/10/26
CRDT- 2013/11/28 06:00
PHST- 2013/07/06 00:00 [received]
PHST- 2013/08/28 00:00 [revised]
PHST- 2013/09/10 00:00 [accepted]
PHST- 2013/11/28 06:00 [entrez]
PHST- 2013/11/28 06:00 [pubmed]
PHST- 2014/06/12 06:00 [medline]
PHST- 2013/10/26 00:00 [pmc-release]
AID - 10.1155/2013/723158 [doi]
PST - ppublish
SO  - Biomed Res Int. 2013;2013:723158. doi: 10.1155/2013/723158. Epub 2013 Oct 26.