PMID- 24283399
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20220321
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 34
IP  - 5
DP  - 2014 Sep
TI  - Influence of exercise intensity on systemic oxidative stress and antioxidant 
      capacity.
PG  - 377-83
LID - 10.1111/cpf.12108 [doi]
AB  - The aim of the current study was to examine the influence of exercise intensity 
      on systemic oxidative stress (OS) and endogenous antioxidant capacity. 
      Non-smoking, sedentary healthy adult males (n = 14) participated in two exercise 
      sessions using an electronically braked cycle ergometer. The first session 
      consisted of a graded exercise test to determine maximal power output and oxygen 
      consumption (VO(2max)). One week later, participants undertook 5-min cycling 
      bouts at 40%, 55%, 70%, 85% and 100% of VO(2max), with passive 12-min rest 
      between stages. Measures of systemic OS reactive oxygen metabolites (dROM), 
      biological antioxidant potential (BAP), heart rate (HR), VO(2), blood lactate and 
      rating of perceived exertion were assessed at rest and immediately following each 
      exercise stage. Significant (P<0.05) differences between exercise bouts were 
      examined via repeated measures ANOVA and post hoc pairwise comparisons with 
      Bonferroni correction. Increasing exercise intensity significantly augmented HR 
      (P<0.001), VO(2) (P<0.001), blood lactate (P<0.001) and perceived exertion 
      (P<0.001) with no significant effect on dROM levels compared with resting values. 
      In contrast, increasing exercise intensity resulted in significantly (P<0.01) 
      greater BAP at 70% (2427 +/- 106), 85% (2625 +/- 121) and 100% (2651 +/- 92) of 
      VO(2max) compared with resting levels (2105 +/- 57 mumol Fe(2+)/L). The current 
      results indicate that brief, moderate-to-high-intensity exercise significantly 
      elevates endogenous antioxidant defences, possibly to counteract increased levels 
      of exercise-induced reactive oxygen species. Regular moderate-to-high-intensity 
      exercise may protect against chronic OS associated diseases via activation, and 
      subsequent upregulation of the endogenous antioxidant defence system.
CI  - (c) 2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. 
      Published by John Wiley & Sons Ltd.
FAU - Parker, Lewan
AU  - Parker L
AD  - College of Sport and Exercise Science, Victoria University, Melbourne, Vic., 
      Australia; Institute of Sport, Exercise and Active Living, Victoria University, 
      Melbourne, Vic., Australia.
FAU - McGuckin, Teneale A
AU  - McGuckin TA
FAU - Leicht, Anthony S
AU  - Leicht AS
LA  - eng
PT  - Journal Article
DEP - 20131127
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Bicycling
MH  - Biomarkers/blood
MH  - *Exercise
MH  - Heart Rate
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - *Muscle Contraction
MH  - Muscle Strength
MH  - Muscle, Skeletal/*metabolism
MH  - *Oxidative Stress
MH  - Oxygen Consumption
MH  - Reactive Oxygen Species/*metabolism
MH  - Sedentary Behavior
MH  - Time Factors
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - chronic disease
OT  - cycle
OT  - hydroperoxide
OT  - physical activity
OT  - reactive oxygen species
OT  - redox
EDAT- 2013/11/29 06:00
MHDA- 2015/05/15 06:00
CRDT- 2013/11/29 06:00
PHST- 2013/10/06 00:00 [received]
PHST- 2013/11/07 00:00 [accepted]
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - 10.1111/cpf.12108 [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2014 Sep;34(5):377-83. doi: 10.1111/cpf.12108. Epub 
      2013 Nov 27.