PMID- 24283549
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20211203
IS  - 1525-1470 (Electronic)
IS  - 0736-8046 (Linking)
VI  - 31
IP  - 1
DP  - 2014 Jan-Feb
TI  - Eczema and sensitization to common allergens in the United States: a multiethnic, 
      population-based study.
PG  - 21-6
LID - 10.1111/pde.12237 [doi]
AB  - The relationship between food and environmental allergens in contributing to 
      eczema risk is unclear on a multiethnic population level. Our purpose was to 
      determine whether sensitization to specific dietary and environmental allergens 
      as measured according to higher specific immunoglobulin E (IgE) levels is 
      associated with eczema risk in children. National Health and Nutrition 
      Examination Survey participants ages 1 to 17 years were asked whether they had 
      ever received a diagnosis of eczema from a physician (n = 538). Total and 
      specific serum IgE levels for four dietary allergens (egg, cow's milk, peanut, 
      and shrimp) and five environmental allergens (dust mite, cat, dog, Aspergillus, 
      and Alternaria) were measured. Logistic regression was used to examine the 
      association between eczema and IgE levels. In the United States, 10.4 million 
      children (15.6%) have a history of eczema. Eczema was more common in black 
      children (p < 0.001) and in children from families with higher income and 
      education (p = 0.01). The median total IgE levels were higher in children with a 
      history of eczema than in those without (66.4 vs 50.6 kU/L, p = 0.004). In 
      multivariate analysis adjusted for age, race, sex, family income, household 
      education, and physician-diagnosed asthma, eczema was significantly associated 
      with sensitization to cat dander (odds ratio [OR] = 1.2, 95% confidence interval 
      [CI] 1.05, 1.4, p = 0.009) and dog dander (OR = 1.5, 95% CI, 1.2, 1.7, p < 
      0.001). After correction for multiple comparisons, only sensitization to dog 
      dander remained significant. U.S. children with eczema are most likely to be 
      sensitized to dog dander. Future prospective studies should further explore this 
      relationship.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Fu, Teresa
AU  - Fu T
AD  - Department of Dermatology, School of Medicine, Stanford University, Redwood City, 
      California.
FAU - Keiser, Elizabeth
AU  - Keiser E
FAU - Linos, Eleni
AU  - Linos E
FAU - Rotatori, Robert M
AU  - Rotatori RM
FAU - Sainani, Kristin
AU  - Sainani K
FAU - Lingala, Bharathi
AU  - Lingala B
FAU - Lane, Alfred T
AU  - Lane AT
FAU - Schneider, Lynda
AU  - Schneider L
FAU - Tang, Jean Y
AU  - Tang JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131127
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Eczema/*epidemiology/*immunology
MH  - Ethnicity/statistics & numerical data
MH  - Female
MH  - Food Hypersensitivity/*ethnology/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Multivariate Analysis
MH  - Nutrition Surveys/*statistics & numerical data
MH  - Prevalence
MH  - Risk Factors
MH  - United States/epidemiology
EDAT- 2013/11/29 06:00
MHDA- 2014/09/24 06:00
CRDT- 2013/11/29 06:00
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
AID - 10.1111/pde.12237 [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2014 Jan-Feb;31(1):21-6. doi: 10.1111/pde.12237. Epub 2013 Nov 
      27.