PMID- 24283657
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20161125
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 85
IP  - 7
DP  - 2014 Jul
TI  - Outcome of enamel matrix derivative treatment in the presence of chronic stress: 
      histometric study in rats.
PG  - e259-67
LID - 10.1902/jop.2013.130383 [doi]
AB  - BACKGROUND: Psychologic stress and clinical hypercortisolism have been related to 
      direct effects on bone metabolism. However, there is a lack of information 
      regarding the outcomes of regenerative approaches under the influence of chronic 
      stress (CS). Enamel matrix derivative (EMD) has been used in periodontal 
      regenerative procedures, resulting in improvement of clinical parameters. Thus, 
      the aim of this histomorphometric study is to evaluate the healing of periodontal 
      defects after treatment with EMD under the influence of CS in the rat model. 
      METHODS: Twenty Wistar rats were randomly assigned to two groups; G1: CS 
      (restraint stress for 12 hours/day) (n = 10), and G2: not exposed to CS (n = 10). 
      Fifteen days after initiation of CS, fenestration defects were created at the 
      buccal aspect of the first mandibular molar of all animals from both groups. 
      After the surgeries, the defects of each animal were randomly assigned to two 
      subgroups: non-treated control and treated with EMD. The animals were euthanized 
      21 days later. RESULTS: G1 showed less bone density (BD) compared to G2. EMD 
      provided an increased defect fill (DF) in G1 and higher BD and new cementum 
      formation (NCF) in both groups. The number of tartrate-resistant acid 
      phosphatase-positive osteoclasts was significantly higher in G1 when compared to 
      G2 and in EMD-treated sites of both groups. CONCLUSIONS: CS may produce a 
      significant detrimental effect on BD. EMD may provide greater DF compared to 
      non-treated control in the presence of CS and increased BD and NCF in the 
      presence or absence of CS.
FAU - Correa, Monica G
AU  - Correa MG
AD  - Department of Prosthodontics and Periodontics, Division of Periodontics, 
      Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil.
FAU - Gomes Campos, Mirella L
AU  - Gomes Campos ML
FAU - Marques, Marcelo Rocha
AU  - Marques MR
FAU - Bovi Ambrosano, Glaucia Maria
AU  - Bovi Ambrosano GM
FAU - Casati, Marcio Z
AU  - Casati MZ
FAU - Nociti, Francisco H Jr
AU  - Nociti FH Jr
FAU - Sallum, Enilson A
AU  - Sallum EA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131128
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Dental Enamel Proteins)
RN  - 0 (Isoenzymes)
RN  - 0 (enamel matrix proteins)
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
SB  - IM
MH  - Acid Phosphatase/analysis
MH  - Alveolar Bone Loss/pathology/*therapy
MH  - Animals
MH  - Bone Density/drug effects/physiology
MH  - Cementogenesis/drug effects/physiology
MH  - Dental Cementum/drug effects/surgery
MH  - Dental Enamel Proteins/*therapeutic use
MH  - Dentin/drug effects/surgery
MH  - Isoenzymes/analysis
MH  - Male
MH  - Mandible/drug effects/pathology
MH  - Osteoclasts/pathology
MH  - Osteogenesis/drug effects/physiology
MH  - Periodontal Ligament/drug effects/surgery
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Physiological/*physiology
MH  - Stress, Psychological/pathology/*physiopathology
MH  - Tartrate-Resistant Acid Phosphatase
OTO - NOTNLM
OT  - Dental cementum
OT  - enamel matrix proteins
OT  - periodontium
OT  - physiological
OT  - rats
OT  - regeneration
OT  - stress
EDAT- 2013/11/29 06:00
MHDA- 2015/05/16 06:00
CRDT- 2013/11/29 06:00
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - 10.1902/jop.2013.130383 [doi]
PST - ppublish
SO  - J Periodontol. 2014 Jul;85(7):e259-67. doi: 10.1902/jop.2013.130383. Epub 2013 
      Nov 28.