PMID- 24284376
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20190727
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 231
IP  - 4
DP  - 2013 Dec
TI  - Urinary fractalkine and monocyte chemoattractant protein-1 as possible predictors 
      of disease activity of childhood glomerulonephritis.
PG  - 265-70
AB  - Renal biopsy is the gold standard for confirmation of disease severity and 
      diagnosis of glomerulonephritis (GN), but its procedure is invasive with a risk 
      of complications. Thus, a non-invasive monitoring method is desirable especially 
      in pediatric patients. Fractalkine and monocyte chemoattractant protein-1 (MCP-1) 
      are proinflammatory chemokines, and both have been reported to be involved in the 
      pathogenesis of immunocomplex-mediated GN. Recently, it has been reported that 
      urinary fractalkine and MCP-1 may serve as possible predictors of disease 
      activity of adult patients with GN. We, therefore, examined whether urinary 
      levels of fractalkine and MCP-1 correlate with clinical and histologic 
      parameters. Twenty-six consecutive children with various types of GN were 
      enrolled in this study, including lupus nephritis, IgA nephropathy, membranous 
      nephropathy, acute GN, and thin basement membrane disease (served as a 
      non-inflammatory control). Urinary fractalkine and MCP-1 concentrations in the 
      first morning urine samples obtained at the time of renal biopsy were measured by 
      enzyme-linked immunosorbent assay, and standardized for urinary creatinine 
      concentrations. Urinary fractalkine concentration differed significantly among 
      the disease categories. Urinary concentrations of fractalkine and MCP-1 showed a 
      significant positive correlation with the degree of occult blood in urine and a 
      significant inverse correlation with the estimated glomerular filtration rate. 
      Furthermore, the urinary MCP-1 concentration was significantly correlated with 
      histological chronicity indices in patients with lupus nephritis and IgA 
      nephropathy. Measurement of urinary fractalkine and MCP-1 concentrations may be 
      useful as a non-invasive method for predicting the disease activity of GN in 
      children.
FAU - Aizawa, Tomomi
AU  - Aizawa T
AD  - Department of Pediatrics, Hirosaki University Hospital.
FAU - Imaizumi, Tadaatsu
AU  - Imaizumi T
FAU - Tsuruga, Kazushi
AU  - Tsuruga K
FAU - Watanabe, Shojiro
AU  - Watanabe S
FAU - Yoshida, Hidemi
AU  - Yoshida H
FAU - Kumagai, Naonori
AU  - Kumagai N
FAU - Ito, Etsuro
AU  - Ito E
FAU - Tanaka, Hiroshi
AU  - Tanaka H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Chemokines)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Biopsy
MH  - Chemokine CCL2/*urine
MH  - Chemokine CX3CL1/*urine
MH  - Chemokines/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Creatinine/urine
MH  - Female
MH  - *Gene Expression Regulation
MH  - Glomerulonephritis/*urine
MH  - Glomerulonephritis, IGA/urine
MH  - Glomerulonephritis, Membranous/urine
MH  - Humans
MH  - Inflammation
MH  - Kidney/pathology
MH  - Lupus Nephritis/urine
MH  - Male
EDAT- 2013/11/29 06:00
MHDA- 2014/07/06 06:00
CRDT- 2013/11/29 06:00
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - DN/JST.JSTAGE/tjem/231.265 [pii]
AID - 10.1620/tjem.231.265 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2013 Dec;231(4):265-70. doi: 10.1620/tjem.231.265.