PMID- 24285177
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20211021
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Jan
TI  - HLA-DPB1 and anti-HBs titer kinetics in hepatitis B booster recipients who 
      completed primary hepatitis B vaccination during infancy.
PG  - 47-53
LID - 10.1038/gene.2013.62 [doi]
AB  - Previously we reported significant associations of the human leukocyte antigen 
      (HLA)-DPB1 05:01 with memory against hepatitis B (HB) vaccination. However, the 
      effects of HLA-DPB1 on antibodies to hepatitis B surface antigen (anti-HBs) 
      kinetics were not explored. We followed up a cohort of 1974 HB booster recipients 
      and quantified their 1-month and 1-year post-booster anti-HBs titers. A total of 
      681 subjects were randomly selected and typed for HLA-DPB1. We found that male 
      subjects, undetectable pre-booster titers, and 05:01 homozygotes led to 
      significantly lower post-booster anti-HBs titers. The geometric means (95% 
      confidence interval (CI)) of 1-month post-booster anti-HBs titers were 4.68 
      (2.69-8.12), 23.01 (14.96-35.40) and 50.06 (27.20-92.13) mIU ml(-1) for subjects 
      carrying two, one and no HLA-DPB1 05:01 allele. The corresponding figures for 
      1-year post-booster anti-HBs titers were 1.26 (0.73-2.18), 4.72 (3.08-7.25) and 
      7.32 (3.75-13.56) mIU ml(-1). There were significant associations of post-booster 
      anti-HBs titers with the number of HLA-DPB1 risk and protective alleles. Among 
      booster responders, anti-HBs decay rates were significantly reduced in subjects 
      who had detectable pre-booster anti-HBs titers and the HLA-DPB1 05:01 allele. Our 
      results indicated that HLA-DPB1 influences the kinetics of anti-HBs. The 
      long-term memory against hepatitis B surface antigen (HBsAg) and the residual 
      serum titers of anti-HBs after HB vaccination may be influenced by different 
      mechanisms as evidenced by their inverse trend of associations with the 05:01 
      allele.
FAU - Wu, T-W
AU  - Wu TW
AD  - Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
FAU - Chu, C-C
AU  - Chu CC
AD  - 1] Immunogenetics Laboratory, Medical Research Department, Mackay Memorial 
      Hospital, Taipei City, Taiwan [2] Department of Bioscience Technology, Chung Yuan 
      Christian University, Chung-Li, Taiwan.
FAU - Liao, H-W Chang
AU  - Liao HW
AD  - Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
FAU - Lin, S-K
AU  - Lin SK
AD  - Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
FAU - Ho, T-Y
AU  - Ho TY
AD  - Institute of Public Health, Tzu Chi University, Hualien, Taiwan.
FAU - Lin, M
AU  - Lin M
AD  - Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial 
      Hospital, New Taipei City, Taiwan.
FAU - Lin, H H
AU  - Lin HH
AD  - 1] Department of Gastroenterology, Buddhist Tzu Chi General Hospital Taipei 
      Branch, New Taipei City, Taiwan [2] Department of Internal Medicine, School of 
      Medicine, Tzu Chi University, Hualien, Taiwan.
FAU - Wang, L-Y
AU  - Wang LY
AD  - 1] Department of Medicine, Mackay Medical College, New Taipei City, Taiwan [2] 
      Institute of Public Health, Tzu Chi University, Hualien, Taiwan [3] Institute of 
      Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131128
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Cohort Studies
MH  - Female
MH  - HLA-DP beta-Chains/*genetics
MH  - Hepatitis B Antibodies/*blood/*immunology
MH  - Hepatitis B Vaccines/*immunology
MH  - Heterozygote
MH  - Humans
MH  - *Immunization, Secondary
MH  - Immunologic Memory
MH  - Infant
MH  - Kinetics
MH  - Linear Models
MH  - Male
EDAT- 2013/11/29 06:00
MHDA- 2014/10/01 06:00
CRDT- 2013/11/29 06:00
PHST- 2013/09/11 00:00 [received]
PHST- 2013/10/21 00:00 [revised]
PHST- 2013/10/24 00:00 [accepted]
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - gene201362 [pii]
AID - 10.1038/gene.2013.62 [doi]
PST - ppublish
SO  - Genes Immun. 2014 Jan;15(1):47-53. doi: 10.1038/gene.2013.62. Epub 2013 Nov 28.