PMID- 24285922
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20220409
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 8
DP  - 2013
TI  - Allergenicity and toxicology of inhaled silver nanoparticles in 
      allergen-provocation mice models.
PG  - 4495-506
LID - 10.2147/IJN.S52239 [doi]
AB  - Silver nanoparticles (AgNP) have been associated with the exacerbation of airway 
      hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy 
      and allergic individuals are unclear. We investigated the pathophysiological 
      responses to AgNP inhalation in a murine model of asthma. Continuous and stable 
      levels of 33 nm AgNP were maintained at 3.3 mg/m(3) during the experimental 
      period. AgNP exposure concomitant with ovalbumin challenge increased the enhanced 
      pause (Penh) in the control and allergic groups. AgNP evoked neutrophil, 
      lymphocyte and eosinophil infiltration into the airways and elevated the levels 
      of allergic markers (immunoglobulin E [IgE] and leukotriene E4 [LTE4]), the type 
      2 T helper (Th2) cytokine interleukin-13 (IL-13), and oxidative stress 
      (8-hydroxy-2'-deoxyguanosine [8-OHdG]) in healthy and allergic mice. 
      Bronchocentric interstitial inflammation was observed after AgNP inhalation. 
      After inhalation, the AgNP accumulated predominantly in the lungs, and trivial 
      amounts of AgNP were excreted in the urine and feces. Furthermore, the AgNP 
      induced inflammatory responses in the peritoneum. The inhalation of AgNP may 
      present safety concerns in healthy and susceptible individuals.
FAU - Chuang, Hsiao-Chi
AU  - Chuang HC
AD  - School of respiratory Therapy, College of Medicine Shuang Ho Hospital, Taipei 
      Medical University, Taipei, Taiwan ; Division of Pulmonary Medicine, Department 
      of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, 
      Taiwan.
FAU - Hsiao, Ta-Chih
AU  - Hsiao TC
FAU - Wu, Cheng-Kuan
AU  - Wu CK
FAU - Chang, Hui-Hsien
AU  - Chang HH
FAU - Lee, Chii-Hong
AU  - Lee CH
FAU - Chang, Chih-Cheng
AU  - Chang CC
FAU - Cheng, Tsun-Jen
AU  - Cheng TJ
CN  - Taiwan CardioPulmonary Research Group (T-CPR)
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131122
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 3M4G523W1G (Silver)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - 9006-59-1 (Ovalbumin)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Administration, Inhalation
MH  - Animals
MH  - Deoxyguanosine/analogs & derivatives/analysis/metabolism
MH  - Female
MH  - Metal Nanoparticles/administration & dosage/chemistry/*toxicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Organ Specificity
MH  - Ovalbumin
MH  - Oxidative Stress/*drug effects
MH  - Pneumonia/*chemically induced/immunology/pathology
MH  - Respiratory Hypersensitivity/immunology
MH  - Silver/administration & dosage/chemistry/*immunology/*toxicity
PMC - PMC3841295
OTO - NOTNLM
OT  - inductively coupled plasma-mass spectrometry
OT  - inflammation
OT  - leukotriene E4
OT  - ovalbumin
OT  - oxidative stress
EDAT- 2013/11/29 06:00
MHDA- 2014/06/10 06:00
PMCR- 2013/11/22
CRDT- 2013/11/29 06:00
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2013/11/22 00:00 [pmc-release]
AID - ijn-8-4495 [pii]
AID - 10.2147/IJN.S52239 [doi]
PST - ppublish
SO  - Int J Nanomedicine. 2013;8:4495-506. doi: 10.2147/IJN.S52239. Epub 2013 Nov 22.