PMID- 24285940
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1674-7984 (Print)
IS  - 1674-7992 (Electronic)
IS  - 1674-7984 (Linking)
VI  - 8
IP  - 5
DP  - 2013 Oct 1
TI  - Novel functions of GABA signaling in adult neurogenesis.
LID - 10.1007/s11515-013-1270-2 [doi]
AB  - Neurotransmitter gamma-aminobutiric acid (GABA) through ionotropic GABA(A) and 
      metabotropic GABA(B) receptors plays key roles in modulating the development, 
      plasticity and function of neuronal networks. GABA is inhibitory in mature 
      neurons but excitatory in immature neurons, neuroblasts and neural 
      stem/progenitor cells (NSCs/NPCs). The switch from excitatory to inhibitory 
      occurs following the development of glutamatergic synaptic input and results from 
      the dynamic changes in the expression of Na(+)/K(+)/2Cl(-) co-transporter NKCC1 
      driving Cl(-) influx and neuron-specific K(+)/Cl(-) co-transporter KCC2 driving 
      Cl(-) efflux. The developmental transition of KCC2 expression is regulated by 
      Disrupted-in-Schizophrenia 1 (DISC1) and brain-derived neurotrophic factor (BDNF) 
      signaling. The excitatory GABA signaling during early neurogenesis is important 
      to the activity/experience-induced regulation of NSC quiescence, NPC 
      proliferation, neuroblast migration and newborn neuronal maturation/functional 
      integration. The inhibitory GABA signaling allows for the sparse and static 
      functional networking essential for learning/memory development and maintenance.
FAU - Pontes, Adalto
AU  - Pontes A
AD  - Department of Neuroscience, Temple University School of Medicine, Philadelphia, 
      PA 19140, USA ; Universidade do Estado do Para, Santarem, PA, Brasil.
FAU - Zhang, Yonggang
AU  - Zhang Y
FAU - Hu, Wenhui
AU  - Hu W
LA  - eng
GR  - R01 DK075964/DK/NIDDK NIH HHS/United States
GR  - R01 MH101041/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - China
TA  - Front Biol (Beijing)
JT  - Frontiers in biology
JID - 101541748
PMC - PMC3839947
MID - NIHMS508311
OTO - NOTNLM
OT  - GABA
OT  - co-transporter
OT  - neural stem cells
OT  - neurogenesis
OT  - neurons
OT  - signal pathways
EDAT- 2013/11/29 06:00
MHDA- 2013/11/29 06:01
PMCR- 2013/11/25
CRDT- 2013/11/29 06:00
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2013/11/29 06:01 [medline]
PHST- 2013/11/25 00:00 [pmc-release]
AID - 10.1007/s11515-013-1270-2 [doi]
PST - ppublish
SO  - Front Biol (Beijing). 2013 Oct 1;8(5):10.1007/s11515-013-1270-2. doi: 
      10.1007/s11515-013-1270-2.