PMID- 24286035
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131128
LR  - 20211021
IS  - 2220-3249 (Print)
IS  - 2220-3249 (Electronic)
IS  - 2220-3249 (Linking)
VI  - 2
IP  - 4
DP  - 2013 Nov 12
TI  - Impact of PRRSV on activation and viability of antigen presenting cells.
PG  - 146-51
LID - 10.5501/wjv.v2.i4.146 [doi]
AB  - Porcine reproductive and respiratory syndrome (PRRS) is one of the most important 
      diseases of swine industry. The causal agent, PRRS-virus (PRRSV), is able to 
      evade the host immune response and survive in the organism causing transient 
      infections. Despite all scientific efforts, there are still some gaps in the 
      knowledge of the pathogenesis of this disease. Antigen presenting cells (APCs), 
      as initiators of the immune response, are located in the first line of defense 
      against microorganisms, and are responsible for antigen recognition, processing 
      and presentation. Dendritic cells (DCs) are the main type of APC involved in 
      antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV 
      replication in DCs may trigger off different mechanisms to impair the onset of a 
      host effective immune response against the virus. On the one side, PRRSV may 
      impair the basic functions of DCs by regulating the expression of major 
      histocompatibility complex class II and CD80/86. Other strategy followed by the 
      virus is the induction of cell death of APCs by apoptosis, necrosis or both of 
      them. The impairment and/or cell death of APCs could lead to a failure in the 
      onset of an efficient immune response, as long as cells could not properly 
      activate T cells. Future aspects to take into account are also discussed in this 
      review.
FAU - Rodriguez-Gomez, Irene M
AU  - Rodriguez-Gomez IM
AD  - Irene M Rodriguez-Gomez, Librado Carrasco, Department of Anatomy and Comparative 
      Pathology, University of Cordoba, 14071 Cordoba, Spain.
FAU - Gomez-Laguna, Jaime
AU  - Gomez-Laguna J
FAU - Carrasco, Librado
AU  - Carrasco L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Virol
JT  - World journal of virology
JID - 101608353
PMC - PMC3832909
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Apoptosis
OT  - CD80/86
OT  - Cell death
OT  - Dendritic cells
OT  - Immune response
OT  - Major histocompatibility complex class II
OT  - Porcine reproductive and respiratory syndrome
EDAT- 2013/11/29 06:00
MHDA- 2013/11/29 06:01
PMCR- 2013/11/12
CRDT- 2013/11/29 06:00
PHST- 2013/06/26 00:00 [received]
PHST- 2013/09/09 00:00 [revised]
PHST- 2013/10/16 00:00 [accepted]
PHST- 2013/11/29 06:00 [entrez]
PHST- 2013/11/29 06:00 [pubmed]
PHST- 2013/11/29 06:01 [medline]
PHST- 2013/11/12 00:00 [pmc-release]
AID - 10.5501/wjv.v2.i4.146 [doi]
PST - ppublish
SO  - World J Virol. 2013 Nov 12;2(4):146-51. doi: 10.5501/wjv.v2.i4.146.