PMID- 24286171
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20181202
IS  - 1476-8321 (Electronic)
IS  - 0887-0446 (Linking)
VI  - 29
IP  - 5
DP  - 2014
TI  - Depressive symptoms in outpatients with heart failure: importance of inflammatory 
      biomarkers, disease severity and personality.
PG  - 564-82
LID - 10.1080/08870446.2013.869813 [doi]
AB  - OBJECTIVE: Depressive symptoms are highly prevalent in heart failure (HF) 
      patients, however the underlying etiology of depression in HF patients remains 
      yet unclear. Hence, the goal is to examine the relative importance of 
      inflammation, disease severity and personality as predictors of depression in HF 
      patients. DESIGN: Depressive symptoms (Hospital Anxiety and Depression Scale, 
      depression subscale) were assessed at baseline and one-year follow-up in 268 HF 
      patients (75.6% men; mean age = 66.7 +/- 8.7). Markers of inflammation (TNFalpha, 
      sTNFr1, sTNFr2, IL-6 and IL-10), disease severity (e.g. New York Heart 
      Association (NYHA) classification) and personality (Type D personality, 
      loneliness) were assessed at baseline. RESULTS: At baseline, NYHA class, body 
      mass index, educational level, Type D personality and loneliness were 
      significantly associated with depression. Higher NYHA class (B = 2.25; SE = .83), 
      higher educational level (B = 1.41; SE = .48), Type D personality (B = 2.56; 
      SE = .60) and loneliness (B = .19; SE = .05) were also independently associated 
      with higher depression levels at one-year follow-up (all p-values < .005). 
      Inflammation, brain natriuretic peptide and left ventricular ejection fraction 
      were not related to depression over time. CONCLUSIONS: Personality factors, but 
      not inflammation, were independent concomitants of depressive symptoms in 
      patients with HF. Gaining more insight into the etiology of depression in HF 
      patients is important in order to identify potential targets for novel 
      interventions.
FAU - Brouwers, Corline
AU  - Brouwers C
AD  - a Department of Medical Psychology and Clinical Psychology, CoRPS-Center of 
      Center of Research on Psychology in Somatic Diseases , Tilburg University , 
      Tilburg , The Netherlands.
FAU - Kupper, Nina
AU  - Kupper N
FAU - Pelle, Aline J
AU  - Pelle AJ
FAU - Szabo, Balasz M
AU  - Szabo BM
FAU - Westerhuis, Bert L W J J M
AU  - Westerhuis BL
FAU - Denollet, Johan
AU  - Denollet J
LA  - eng
PT  - Journal Article
DEP - 20140103
PL  - England
TA  - Psychol Health
JT  - Psychology & health
JID - 8807983
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factors)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Depression/blood/*etiology/psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*psychology
MH  - Humans
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Outpatients/*psychology/statistics & numerical data
MH  - Personality
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factors/blood
EDAT- 2013/11/30 06:00
MHDA- 2014/04/22 06:00
CRDT- 2013/11/30 06:00
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - 10.1080/08870446.2013.869813 [doi]
PST - ppublish
SO  - Psychol Health. 2014;29(5):564-82. doi: 10.1080/08870446.2013.869813. Epub 2014 
      Jan 3.