PMID- 24286189
OWN - NLM
STAT- MEDLINE
DCOM- 20140804
LR  - 20220419
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 15
IP  - 5
DP  - 2013 Oct 4
TI  - HLA and non-HLA genes in Behcet's disease: a multicentric study in the Spanish 
      population.
PG  - R145
LID - 10.1186/ar4328 [doi]
AB  - INTRODUCTION: According to genome wide association (GWA) studies as well as 
      candidate gene approaches, Behcet's disease (BD) is associated with human 
      leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been 
      consistently associated with the disease, but the role of other HLA class I 
      molecules remains controversial. Recently, variants in non-HLA genes have also 
      been associated with BD. The aims of this study were to further investigate the 
      influence of the HLA region in BD and to explore the relationship with non-HLA 
      genes recently described to be associated in other populations. METHODS: This 
      study included 304 BD patients and 313 ethnically matched controls. HLA-A and 
      HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag 
      single nucleotide polymorphisms (SNPs) located outside of the HLA-region, 
      previously described associated with the disease in GWA studies and having a 
      minor allele frequency in Caucasians greater than 0.15 were genotyped using 
      TaqMan assays. Phenotypic and genotypic frequencies were estimated by direct 
      counting and distributions were compared using the chi(2) test. RESULTS: In 
      addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 
      was found to be protective. Other HLA-A and B specificities were suggestive of 
      association with the disease as risk (A*02 and A*24) or protective factors (A*03 
      and B*58). Regarding the non-HLA genes, the three SNPs located in IL23R and one 
      of the SNPs in IL10 were found to be significantly associated with susceptibility 
      to BD in our population. CONCLUSION: Different HLA specificities are associated 
      with Behcet's disease in addition to B*51. Other non-HLA genes, such as IL23R and 
      IL-10, play a role in the susceptibility to the disease.
FAU - Montes-Cano, Marco Antonio
AU  - Montes-Cano MA
FAU - Conde-Jaldon, Marta
AU  - Conde-Jaldon M
FAU - Garcia-Lozano, Jose Raul
AU  - Garcia-Lozano JR
FAU - Ortiz-Fernandez, Lourdes
AU  - Ortiz-Fernandez L
FAU - Ortego-Centeno, Norberto
AU  - Ortego-Centeno N
FAU - Castillo-Palma, Maria Jesus
AU  - Castillo-Palma MJ
FAU - Espinosa, Gerard
AU  - Espinosa G
FAU - Grana-Gil, Genaro
AU  - Grana-Gil G
FAU - Gonzalez-Gay, Miguel Angel
AU  - Gonzalez-Gay MA
FAU - Barnosi-Marin, Ana Celia
AU  - Barnosi-Marin AC
FAU - Solans, Roser
AU  - Solans R
FAU - Fanlo, Patricia
AU  - Fanlo P
FAU - Camps, Teresa
AU  - Camps T
FAU - Castaneda, Santos
AU  - Castaneda S
FAU - Sanchez-Burson, Juan
AU  - Sanchez-Burson J
FAU - Nunez-Roldan, Antonio
AU  - Nunez-Roldan A
FAU - Martin, Javier
AU  - Martin J
FAU - Gonzalez-Escribano, Maria Francisca
AU  - Gonzalez-Escribano MF
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20131004
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B35 Antigen)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-B57 antigen)
RN  - 0 (IL23R protein, human)
RN  - 0 (Receptors, Interleukin)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome-Wide Association Study/methods
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-B35 Antigen/genetics
MH  - HLA-B51 Antigen/genetics
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin/*genetics
MH  - Risk Factors
MH  - Spain
PMC - PMC3978908
EDAT- 2013/11/30 06:00
MHDA- 2014/08/05 06:00
PMCR- 2013/10/04
CRDT- 2013/11/30 06:00
PHST- 2012/10/04 00:00 [received]
PHST- 2013/09/19 00:00 [accepted]
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/08/05 06:00 [medline]
PHST- 2013/10/04 00:00 [pmc-release]
AID - ar4328 [pii]
AID - 10.1186/ar4328 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2013 Oct 4;15(5):R145. doi: 10.1186/ar4328.