PMID- 24287320
OWN - NLM
STAT- MEDLINE
DCOM- 20141022
LR  - 20140217
IS  - 1873-3379 (Electronic)
IS  - 0891-4222 (Linking)
VI  - 35
IP  - 3
DP  - 2014 Mar
TI  - Chronic kidney disease in older people with intellectual disability: results of 
      the HA-ID study.
PG  - 726-32
LID - S0891-4222(13)00492-7 [pii]
LID - 10.1016/j.ridd.2013.11.005 [doi]
AB  - With increasing longevity and cardiovascular events, chronic kidney disease may 
      also become a significant problem in older people with intellectual disability 
      (ID). We studied prevalence and associations of chronic kidney disease as part of 
      the Healthy Ageing and Intellectual Disability (HA-ID) study, a large Dutch 
      cross-sectional study among people with ID aged 50 years and over, using 
      creatinine and cystatin-C measurement in plasma. Glomerular filtration rate (GFR) 
      was calculated using the Modification of Diet in Renal Disease (MDRD) and Chronic 
      Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Equations based on 
      creatinine (as the MDRD equation) may underestimate kidney dysfunction in people 
      with sarcopenia, because low muscle mass leads to a low creatinine production. 
      Therefore, also prevalence of chronic kidney disease was studied in the 
      sarcopenic group, using different GFR equations. Prevalence of chronic kidney 
      disease, among 635 participants, was 15.3%, which equals prevalence in the 
      general Dutch population. In the group of participants with sarcopenia (n=82), 
      the CKD-EPI equation based on creatinine and cystatin-C gave a higher prevalence 
      of chronic kidney disease than did the MDRD equation, but confidence intervals 
      were very wide. Chronic kidney disease was associated with higher age, Down 
      syndrome, obesity, hypercholesterolemia and hypothyroid disease. GFR should be 
      measured in all older people with ID and polypharmacy, and in older people with 
      ID and Down syndrome as part of the regular health checks. Moreover, if 
      sarcopenia is present and information on GFR is required, this should not be 
      measured based on creatinine only, but additional measures, such as cystatin-C, 
      should be taken into account.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - de Winter, C F
AU  - de Winter CF
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands; Reinaerde, Den Dolder, The 
      Netherlands. Electronic address: channadewinter@hotmail.com.
FAU - Echteld, M A
AU  - Echteld MA
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
FAU - Evenhuis, H M
AU  - Evenhuis HM
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131125
PL  - United States
TA  - Res Dev Disabil
JT  - Research in developmental disabilities
JID - 8709782
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Cystatin C/blood
MH  - Down Syndrome/epidemiology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hypercholesterolemia/epidemiology
MH  - Hypothyroidism/epidemiology
MH  - Intellectual Disability/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Obesity/epidemiology
MH  - Polypharmacy
MH  - Prevalence
MH  - Renal Insufficiency, Chronic/diagnosis/*epidemiology
MH  - Risk Factors
MH  - Sarcopenia/blood/epidemiology
OTO - NOTNLM
OT  - Down syndrome
OT  - Intellectual disability
OT  - Kidney disease
OT  - Prevalence
OT  - Renal dysfunction
EDAT- 2013/11/30 06:00
MHDA- 2014/10/23 06:00
CRDT- 2013/11/30 06:00
PHST- 2013/09/23 00:00 [received]
PHST- 2013/11/04 00:00 [revised]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/10/23 06:00 [medline]
AID - S0891-4222(13)00492-7 [pii]
AID - 10.1016/j.ridd.2013.11.005 [doi]
PST - ppublish
SO  - Res Dev Disabil. 2014 Mar;35(3):726-32. doi: 10.1016/j.ridd.2013.11.005. Epub 
      2013 Nov 25.