PMID- 24287454
OWN - NLM
STAT- MEDLINE
DCOM- 20140815
LR  - 20220331
IS  - 1879-3088 (Electronic)
IS  - 0962-8924 (Linking)
VI  - 24
IP  - 1
DP  - 2014 Jan
TI  - ALIX and the multivesicular endosome: ALIX in Wonderland.
PG  - 19-25
LID - S0962-8924(13)00190-6 [pii]
LID - 10.1016/j.tcb.2013.10.009 [doi]
AB  - In yeast and mammalian cells, endosomal sorting complexes required for transport 
      (ESCRT) assist in sorting ubiquitinated proteins into intralumenal vesicles 
      (ILVs) of multivesicular endosomes (MVEs) for degradation in the 
      lysosome/vacuole. In mammalian cells, ESCRTs also drive other topologically 
      identical membrane deformation processes, including cytokinesis, exosome release, 
      and virus budding. Although the ESCRT-associated protein ALIX regulates these 
      mammalian cell-specific functions, it was believed to be dispensable for receptor 
      sorting into ILVs, unlike its yeast homolog Bro1. Despite these differences, 
      recent evidence suggests ALIX and Bro1 share common properties in cargo sorting 
      and ILV formation. We review these commonalities and discuss the role of ALIX in 
      operating 'behind the mirror' during ILV back-fusion with the limiting membrane. 
      We also propose models of how ALIX and some ESCRTs regulate the back-fusion 
      process.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Bissig, Christin
AU  - Bissig C
AD  - Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 
      Geneva-4, Switzerland.
FAU - Gruenberg, Jean
AU  - Gruenberg J
AD  - Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 
      Geneva-4, Switzerland. Electronic address: jean.gruenberg@unige.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131126
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Bro1 protein, S cerevisiae)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
RN  - 0 (PDCD6IP protein, human)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Ubiquitinated Proteins)
SB  - IM
MH  - Animals
MH  - Calcium-Binding Proteins/*physiology
MH  - Cell Cycle Proteins/*physiology
MH  - Cell Membrane/metabolism/ultrastructure
MH  - Endosomal Sorting Complexes Required for Transport/*physiology
MH  - Humans
MH  - Multivesicular Bodies/*metabolism
MH  - Protein Transport
MH  - Saccharomyces cerevisiae Proteins/physiology
MH  - Transport Vesicles/metabolism
MH  - Ubiquitinated Proteins/metabolism
OTO - NOTNLM
OT  - Bro1
OT  - EGF receptor
OT  - ESCRT-mediated sorting
OT  - back-fusion
OT  - intralumenal vesicle (ILV)
OT  - signaling receptor
EDAT- 2013/11/30 06:00
MHDA- 2014/08/16 06:00
CRDT- 2013/11/30 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2013/10/29 00:00 [revised]
PHST- 2013/10/30 00:00 [accepted]
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/08/16 06:00 [medline]
AID - S0962-8924(13)00190-6 [pii]
AID - 10.1016/j.tcb.2013.10.009 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2014 Jan;24(1):19-25. doi: 10.1016/j.tcb.2013.10.009. Epub 2013 
      Nov 26.