PMID- 24288402
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220419
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 87
IP  - 1034
DP  - 2014 Feb
TI  - Co-registration of cone beam CT and planning CT in head and neck IMRT dose 
      estimation: a feasible adaptive radiotherapy strategy.
PG  - 20130532
LID - 10.1259/bjr.20130532 [doi]
LID - 20130532
AB  - OBJECTIVE: To investigate if cone beam CT (CBCT) can be used to estimate the 
      delivered dose in head and neck intensity-modulated radiotherapy (IMRT). METHODS: 
      15 patients (10 without replan and 5 with replan) were identified 
      retrospectively. Weekly CBCT was co-registered with original planning CT. 
      Original high-dose clinical target volume (CTV1), low-dose CTV (CTV2), brainstem, 
      spinal cord, parotids and external body contours were copied to each CBCT and 
      modified to account for anatomical changes. Corresponding planning target volumes 
      (PTVs) and planning organ-at-risk volumes were created. The original plan was 
      applied and calculated using modified per-treatment volumes on the original CT. 
      Percentage volumetric, cumulative (planned dose delivered prior to CBCT + 
      adaptive dose delivered after CBCT) and actual delivered (summation of weekly 
      adaptive doses) dosimetric differences between each per-treatment and original 
      plan were calculated. RESULTS: There was greater volumetric change in the 
      parotids with an average weekly difference of between -4.1% and -27.0% compared 
      with the CTVs/PTVs (-1.8% to -5.0%). The average weekly cumulative dosimetric 
      differences were as follows: CTV/PTV (range, -3.0% to 2.2%), ipsilateral parotid 
      volume receiving >/=26 Gy (V26) (range, 0.5-3.2%) and contralateral V26 (range, 
      1.9-6.3%). In patients who required replan, the average volumetric reductions 
      were greater: CTV1 (-2.5%), CTV2 (-6.9%), PTV1 (-4.7%), PTV2 (-11.5%), 
      ipsilateral (-10.4%) and contralateral parotids (-12.1%), but did not result in 
      significant dosimetric changes. CONCLUSION: The dosimetric changes during head 
      and neck simultaneous integrated boost IMRT do not necessitate adaptive 
      radiotherapy in most patients. ADVANCES IN KNOWLEDGE: Our study shows that CBCT 
      could be used for dose estimation during head and neck IMRT.
FAU - Yip, C
AU  - Yip C
AD  - Department of Oncology, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation 
      Trust, London, UK.
FAU - Thomas, C
AU  - Thomas C
FAU - Michaelidou, A
AU  - Michaelidou A
FAU - James, D
AU  - James D
FAU - Lynn, R
AU  - Lynn R
FAU - Lei, M
AU  - Lei M
FAU - Guerrero Urbano, T
AU  - Guerrero Urbano T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131128
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/diagnostic imaging/*radiotherapy
MH  - Cone-Beam Computed Tomography
MH  - Feasibility Studies
MH  - Female
MH  - Head and Neck Neoplasms/diagnostic imaging/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Image-Guided/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Retrospective Studies
PMC - PMC4064545
EDAT- 2013/11/30 06:00
MHDA- 2014/03/07 06:00
PMCR- 2015/02/01
CRDT- 2013/11/30 06:00
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - bjr.20130532 [pii]
AID - 10.1259/bjr.20130532 [doi]
PST - ppublish
SO  - Br J Radiol. 2014 Feb;87(1034):20130532. doi: 10.1259/bjr.20130532. Epub 2013 Nov 
      28.