PMID- 24288552
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2013
DP  - 2013
TI  - Induction of Th17 lymphocytes and Treg cells by monocyte-derived dendritic cells 
      in patients with rheumatoid arthritis and systemic lupus erythematosus.
PG  - 584303
LID - 10.1155/2013/584303 [doi]
LID - 584303
AB  - Dendritic cells (DCs) have a key role in the regulation of immune response. We 
      herein explored, in patients with inflammatory diseases, the role of monocyte 
      derived DC's (mo-DCs) on the generation of Th17 and T regulatory (Treg) 
      lymphocytes. Peripheral blood was obtained from thirty-five patients with 
      rheumatoid arthritis (RA), twelve with systemic lupus erythematosus (SLE), and 
      twenty healthy subjects. Mo-DCs were generated under standard (IL-4/GM-CSF) or 
      tolerogenic (IL-4/GM-CSF plus recombinant P-selectin or PD-1 or IL-10) 
      conditions, and their ability to induce Th17 and Treg lymphocytes was tested. We 
      detected that mo-DCs from patients with RA showed an enhanced release of IL-6 and 
      IL-23 as well as an increased capability to induce Th17 cells. Although mo-DCs 
      from SLE patients also released high levels of IL-6/IL-23, it did not show an 
      increased ability to induce Th17 lymphocytes. In addition, mo-DCs, from patients 
      with RA and SLE generated under the engagement of PSGL-1, showed a defective 
      capability to induce Foxp3+ Treg cells. A similar phenomenon was observed in SLE, 
      when DC's cells were generated under PDL-1 engagement. Our data indicate that DCs 
      from patients with rheumatic inflammatory disease show an aberrant function that 
      may have an important role in the pathogenesis of these conditions.
FAU - Estrada-Capetillo, Lizbeth
AU  - Estrada-Capetillo L
AD  - Department of Immunology, Facultad de Medicina, UASLP, Avenue V. Carranza 2405, 
      78210 San Luis Potosi, SLP, Mexico.
FAU - Hernandez-Castro, Berenice
AU  - Hernandez-Castro B
FAU - Monsivais-Urenda, Adriana
AU  - Monsivais-Urenda A
FAU - Alvarez-Quiroga, Crisol
AU  - Alvarez-Quiroga C
FAU - Layseca-Espinosa, Esther
AU  - Layseca-Espinosa E
FAU - Abud-Mendoza, Carlos
AU  - Abud-Mendoza C
FAU - Baranda, Lourdes
AU  - Baranda L
FAU - Urzainqui, Ana
AU  - Urzainqui A
FAU - Sanchez-Madrid, Francisco
AU  - Sanchez-Madrid F
FAU - Gonzalez-Amaro, Roberto
AU  - Gonzalez-Amaro R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131029
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arthritis, Rheumatoid/*immunology/metabolism
MH  - Cell Differentiation
MH  - Coculture Techniques
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Lupus Erythematosus, Systemic/*immunology/metabolism
MH  - Middle Aged
MH  - Phenotype
MH  - T-Lymphocytes, Regulatory/cytology/*immunology/metabolism
MH  - Th17 Cells/cytology/*immunology/metabolism
MH  - Young Adult
PMC - PMC3830818
EDAT- 2013/11/30 06:00
MHDA- 2014/06/10 06:00
PMCR- 2013/10/29
CRDT- 2013/11/30 06:00
PHST- 2013/05/01 00:00 [received]
PHST- 2013/09/05 00:00 [accepted]
PHST- 2013/11/30 06:00 [entrez]
PHST- 2013/11/30 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2013/10/29 00:00 [pmc-release]
AID - 10.1155/2013/584303 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2013;2013:584303. doi: 10.1155/2013/584303. Epub 2013 Oct 29.