PMID- 24288972
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20151119
IS  - 0385-2385 (Print)
IS  - 0385-2385 (Linking)
VI  - 55
IP  - 7
DP  - 2013
TI  - [Case of pseudohypercreatininemia associated with monoclonal IgM gammopathy].
PG  - 1340-4
AB  - An 80-year-old man with well controlled hypertension for eight years and 
      monoclonal IgM gammopathy was referred to our hospital in May 2010 due to 
      persistent elevation of serum creatinine(s-Cr). At our hospital, urine and blood 
      tests showed no abnormal findings as BUN and Cr were 15.0 mg/dL and 0.91 mg/dL, 
      respectively. In contrast the referring hospital had obtained values of 10.4 
      mg/dL and 4.8 mg/dL, respectively. This discrepancy was replicated when s-Cr was 
      measured in another sample from this patient using the enzyme assay kits employed 
      by the referring hospital and our hospital. High-performance liquid 
      chromatography (HPLC), which is the standard method for measuring s-Cr, gave a 
      value in the normal range. After removing high molecular weight proteins (>3,000 
      D)from the serum sample, the s-Cr levels measured with the respective kits were 
      similar. Since elevation of s-Cr was linked to that of IgM at the referring 
      hospital, we diagnosed the patient as having pseudohypercreatininemia with 
      monoclonal IgM gammopathy.
FAU - Ikeda, Masaki
AU  - Ikeda M
AD  - Department of Nephrology & Dialysis, Tazuke Kofukai Foundation, Medical Research 
      Institute, Kitano Hospital, Osaka, Japan.
FAU - Tsukamoto, Tatsuo
AU  - Tsukamoto T
FAU - Miyake, Takafumi
AU  - Miyake T
FAU - Kakita, Hiroko
AU  - Kakita H
FAU - Komiya, Toshiyuki
AU  - Komiya T
FAU - Yonemoto, Satomi
AU  - Yonemoto S
FAU - Muso, Eri
AU  - Muso E
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Jinzo Gakkai Shi
JT  - Nihon Jinzo Gakkai shi
JID - 7505731
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Reagent Kits, Diagnostic)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Blood Urea Nitrogen
MH  - Chromatography, High Pressure Liquid
MH  - Creatine/*blood
MH  - Enzyme Assays/methods
MH  - Humans
MH  - Immunoglobulin M/*blood
MH  - Male
MH  - Paraproteinemias/*blood/*diagnosis
MH  - Reagent Kits, Diagnostic
EDAT- 2013/12/03 06:00
MHDA- 2014/01/30 06:00
CRDT- 2013/12/03 06:00
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
PST - ppublish
SO  - Nihon Jinzo Gakkai Shi. 2013;55(7):1340-4.